| Reaction Details |
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 | Report a problem with these data |
| Target | Purine nucleoside phosphorylase |
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| Ligand | BDBM50046239 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_153323 (CHEMBL873308) |
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| Ki | 15±n/a nM |
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| Citation |  Montgomery, JA; Niwas, S; Rose, JD; Secrist, JA; Babu, YS; Bugg, CE; Erion, MD; Guida, WC; Ealick, SE Structure-based design of inhibitors of purine nucleoside phosphorylase. 1. 9-(arylmethyl) derivatives of 9-deazaguanine. J Med Chem36:55-69 (1993) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Purine nucleoside phosphorylase |
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| Name: | Purine nucleoside phosphorylase |
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| Synonyms: | Inosine phosphorylase | NP | PNP | PNPH_BOVIN | Purine Nucleoside Phosphorylase (PNP) | Purine nucleoside phosphorylase |
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| Type: | Enzyme |
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| Mol. Mass.: | 32035.18 |
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| Organism: | Bos taurus (bovine) |
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| Description: | n/a |
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| Residue: | 289 |
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| Sequence: | MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPEST
VPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGL
NPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQ
MGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSL
ITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG
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| BDBM50046239 |
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| n/a |
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| Name | BDBM50046239 |
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| Synonyms: | 2-Amino-9-thiophen-3-ylmethyl-1,9-dihydro-purin-6-one | CHEMBL159640 |
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| Type | Small organic molecule |
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| Emp. Form. | C11H12N4OS |
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| Mol. Mass. | 248.304 |
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| SMILES | Nc1nc2C(Cc3ccsc3)CNc2c(=O)[nH]1 |
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| Structure | 
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