| Reaction Details |
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 | Report a problem with these data |
| Target | Purine nucleoside phosphorylase |
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| Ligand | BDBM50046235 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_153325 |
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| IC50 | 48±n/a nM |
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| Citation |  Montgomery, JA; Niwas, S; Rose, JD; Secrist, JA; Babu, YS; Bugg, CE; Erion, MD; Guida, WC; Ealick, SE Structure-based design of inhibitors of purine nucleoside phosphorylase. 1. 9-(arylmethyl) derivatives of 9-deazaguanine. J Med Chem36:55-69 (1993) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Purine nucleoside phosphorylase |
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| Name: | Purine nucleoside phosphorylase |
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| Synonyms: | Inosine phosphorylase | Inosine-guanosine phosphorylase | NP | PNP | PNPH_HUMAN | Purine nucleoside phosphorylase (PNPase) |
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| Type: | Enzyme |
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| Mol. Mass.: | 32119.53 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 289 |
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| Sequence: | MENGYTYEDYKNTAEWLLSHTKHRPQVAIICGSGLGGLTDKLTQAQIFDYGEIPNFPRST
VPGHAGRLVFGFLNGRACVMMQGRFHMYEGYPLWKVTFPVRVFHLLGVDTLVVTNAAGGL
NPKFEVGDIMLIRDHINLPGFSGQNPLRGPNDERFGDRFPAMSDAYDRTMRQRALSTWKQ
MGEQRELQEGTYVMVAGPSFETVAECRVLQKLGADAVGMSTVPEVIVARHCGLRVFGFSL
ITNKVIMDYESLEKANHEEVLAAGKQAAQKLEQFVSILMASIPLPDKAS
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| BDBM50046235 |
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| n/a |
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| Name | BDBM50046235 |
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| Synonyms: | 2-Amino-8-(3-methyl-thiophen-2-ylmethyl)-1,9-dihydro-purin-6-one | CHEMBL159556 |
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| Type | Small organic molecule |
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| Emp. Form. | C11H11N5OS |
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| Mol. Mass. | 261.303 |
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| SMILES | Cc1ccsc1Cc1nc2nc(N)[nH]c(=O)c2[nH]1 |
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| Structure | 
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