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TargetLanosterol 14-alpha demethylase
LigandBDBM50046560
Substrate/Competitorn/a
Meas. Tech.ChEMBL_147858 (CHEMBL754770)
IC50 300±n/a nM
Citation Frye, LLCusack, KPLeonard, DA 32-Methyl-32-oxylanosterols: dual-action inhibitors of cholesterol biosynthesis. J Med Chem36:410-6 (1993) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
Lanosterol 14-alpha demethylase
Name:Lanosterol 14-alpha demethylase
Synonyms:CP51A_RAT | CYPLI | Cyp51 | Cyp51a1 | Cytochrome P450 51 | Cytochrome P450 51A1 | LDM | Lanosterol 14-alpha demethylase | P450-14DM | P45014DM | P450LI | Sterol 14-alpha demethylase
Type:PROTEIN
Mol. Mass.:56717.47
Organism:Rattus norvegicus
Description:ChEMBL_52075
Residue:503
Sequence:
MVLLGLLQSGGSVLGQAMEQVTGGNLLSTLLIACAFTLSLVYLFRLAVGHMVQLPAGAKS
PPYIYSPIPFLGHAIAFGKSPIEFLENAYEKYGPVFSFTMVGKTFTYLLGSDAAALLFNS
KNEDLNAEEVYGRLTTPVFGKGVAYDVPNAVFLEQKKILKSGLNIAHFKQYVSIIEKEAK
EYFKSWGESGERNVFEALSELIILTASHCLHGKEIRSQLNEKVAQLYADLDGGFSHAAWL
LPGWLPLPSFRRRDRAHREIKNIFYKAIQKRRLSKEPAEDILQTLLDSTYKDGRPLTDDE
IAGMLIGLLLAGQHTSSTTSAWMGFFLARDKPLQDKCYLEQKTVCGEDLPPLTYEQLKDL
NLLDRCIKETLRLRPPIMTMMRMAKTPQTVAGYTIPPGHQVCVSPTVNQRLKDSWVERLD
FNPDRYLQDNPASGEKFAYVPFGAGRHRCIGENFAYVQIKTIWSTMLRLYEFDLINGYFP
SVNYTTMIHTPENPVIRYKRRSK
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50046560
n/a
NameBDBM50046560
Synonyms:17-(1,5-Dimethyl-hexyl)-14-(1-hydroxy-ethyl)-4,4,10,13-tetramethyl-2,3,4,5,6,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-ol | CHEMBL133834
TypeSmall organic molecule
Emp. Form.C31H54O2
Mol. Mass.458.7593
SMILESCC(C)CCC[C@@H](C)[C@H]1CC[C@@]2(C(C)O)C3=CCC4C(C)(C)[C@@H](O)CC[C@]4(C)C3CC[C@]12C |t:15|
Structure
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