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TargetThymidylate synthase
LigandBDBM50046657
Substrate/Competitorn/a
Meas. Tech.ChEMBL_219323 (CHEMBL823516)
Ki 16±n/a nM
Citation Webber, SEBleckman, TMAttard, JDeal, JGKathardekar, VWelsh, KMWebber, SJanson, CAMatthews, DASmith, WW Design of thymidylate synthase inhibitors using protein crystal structures: the synthesis and biological evaluation of a novel class of 5-substituted quinazolinones. J Med Chem36:733-46 (1993) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
Thymidylate synthase
Name:Thymidylate synthase
Synonyms:TS | TSase | TYMS | TYSY_HUMAN | Thymidylate synthase (TS) | Thymidylate synthase/GAR transformylase/AICAR transformylase
Type:Enzyme
Mol. Mass.:35718.07
Organism:Homo sapiens (Human)
Description:n/a
Residue:313
Sequence:
MPVAGSELPRRPLPPAAQERDAEPRPPHGELQYLGQIQHILRCGVRKDDRTGTGTLSVFG
MQARYSLRDEFPLLTTKRVFWKGVLEELLWFIKGSTNAKELSSKGVKIWDANGSRDFLDS
LGFSTREEGDLGPVYGFQWRHFGAEYRDMESDYSGQGVDQLQRVIDTIKTNPDDRRIIMC
AWNPRDLPLMALPPCHALCQFYVVNSELSCQLYQRSGDMGLGVPFNIASYALLTYMIAHI
TGLKPGDFIHTLGDAHIYLNHIEPLKIQLQREPRPFPKLRILRKVEKIDDFKAEDFQIEG
YNPHPTIKMEMAV
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  Blast E-value cutoff:
BDBM50046657
n/a
NameBDBM50046657
Synonyms:2-Amino-6-methyl-5-(pyridin-4-ylsulfanyl)-3H-quinazolin-4-one | CHEMBL320775
TypeSmall organic molecule
Emp. Form.C14H12N4OS
Mol. Mass.284.336
SMILESCc1ccc2nc(N)[nH]c(=O)c2c1Sc1ccncc1
Structure
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