Reaction Details |
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Target | Renin |
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Ligand | BDBM50046785 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_195746 (CHEMBL801598) |
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pH | 7.4±n/a |
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IC50 | 2.8±n/a nM |
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Comments | extracted |
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Citation | Rosenberg, SH; Spina, KP; Woods, KW; Polakowski, J; Martin, DL; Yao, Z; Stein, HH; Cohen, J; Barlow, JL; Egan, DA Studies directed toward the design of orally active renin inhibitors. 1. Some factors influencing the absorption of small peptides. J Med Chem36:449-59 (1993) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Renin |
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Name: | Renin |
Synonyms: | Angiotensinogenase | REN | RENI_HUMAN |
Type: | Enzyme |
Mol. Mass.: | 45058.99 |
Organism: | Homo sapiens (Human) |
Description: | n/a |
Residue: | 406 |
Sequence: | MDGWRRMPRWGLLLLLWGSCTFGLPTDTTTFKRIFLKRMPSIRESLKERGVDMARLGPEW
SQPMKRLTLGNTTSSVILTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRL
YTACVYHKLFDASDSSSYKHNGTELTLRYSTGTVSGFLSQDIITVGGITVTQMFGEVTEM
PALPFMLAEFDGVVGMGFIEQAIGRVTPIFDNIISQGVLKEDVFSFYYNRDSENSQSLGG
QIVLGGSDPQHYEGNFHYINLIKTGVWQIQMKGVSVGSSTLLCEDGCLALVDTGASYISG
STSSIEKLMEALGAKKRLFDYVVKCNEGPTLPDISFHLGGKEYTLTSADYVFQESYSSKK
LCTLAIHAMDIPPPTGPTWALGATFIRKFYTEFDRRNNRIGFALAR
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BDBM50046785 |
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n/a |
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Name | BDBM50046785 |
Synonyms: | 2-Benzyl-N-[1-(1-cyclohexylmethyl-2,3-dihydroxy-5-methyl-hexylcarbamoyl)-2-(1H-pyrazol-3-yl)-ethyl]-4-(4-methyl-piperazin-1-yl)-4-oxo-butyramide | CHEMBL423182 |
Type | Small organic molecule |
Emp. Form. | C36H56N6O5 |
Mol. Mass. | 652.867 |
SMILES | CC(C)C[C@H](O)[C@H](O)[C@H](CC1CCCCC1)NC(=O)[C@H](Cc1ccn[nH]1)NC(=O)[C@@H](CC(=O)N1CCN(C)CC1)Cc1ccccc1 |
Structure |
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