Reaction Details |
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Target | Sodium-dependent serotonin transporter |
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Ligand | BDBM50047091 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_198045 (CHEMBL804187) |
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IC50 | 1.1±n/a nM |
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Citation | Malleron, JL; Guérémy, C; Mignani, S; Peyronel, JF; Truchon, A; Blanchard, JC; Doble, A; Laduron, P; Piot, O; Zundel, JL New indole derivatives as potent and selective serotonin uptake inhibitors. J Med Chem36:1194-202 (1993) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Sodium-dependent serotonin transporter |
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Name: | Sodium-dependent serotonin transporter |
Synonyms: | 5-HT Transporter | 5-HTT | 5HT transporter | 5HTT | Anandamid membrane transporter, AMT | Anandamide membrane transporter, AMT | Monoamine transporters; Norepinephrine & serotonin | SC6A4_RAT | Slc6a4 | Sodium-dependent serotonin transporter | Sodium-dependent serotonin transporter (SERT) | imipramine receptor |
Type: | Multi-pass membrane protein |
Mol. Mass.: | 70168.43 |
Organism: | Rattus norvegicus (rat) |
Description: | P31652 |
Residue: | 630 |
Sequence: | METTPLNSQKVLSECKDREDCQENGVLQKGVPTTADRAEPSQISNGYSAVPSTSAGDEAS
HSIPAATTTLVAEIRQGERETWGKKMDFLLSVIGYAVDLGNIWRFPYICYQNGGGAFLLP
YTIMAIFGGIPLFYMELALGQYHRNGCISIWRKICPIFKGIGYAICIIAFYIASYYNTII
AWALYYLISSLTDRLPWTSCTNSWNTGNCTNYFAQDNITWTLHSTSPAEEFYLRHVLQIH
QSKGLQDLGTISWQLTLCIVLIFTVIYFSIWKGVKTSGKVVWVTATFPYIVLSVLLVRGA
TLPGAWRGVVFYLKPNWQKLLETGVWVDAAAQIFFSLGPGFGVLLAFASYNKFNNNCYQD
ALVTSVVNCMTSFVSGFVIFTVLGYMAEMRNEDVSEVAKDAGPSLLFITYAEAIANMPAS
TFFAIIFFLMLITLGLDSTFAGLEGVITAVLDEFPHIWAKRREWFVLIVVITCVLGSLLT
LTSGGAYVVTLLEEYATGPAVLTVALIEAVAVSWFYGITQFCSDVKEMLGFSPGWFWRIC
WVAISPLFLLFIICSFLMSPPQLRLFQYNYPHWSIVLGYCIGMSSVICIPTYIIYRLIST
PGTLKERIIKSITPETPTEIPCGDIRMNAV
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BDBM50047091 |
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n/a |
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Name | BDBM50047091 |
Synonyms: | 2-{2-[4-(5-Fluoro-1H-indol-3-ylmethyl)-3,6-dihydro-2H-pyridin-1-yl]-ethyl}-2H-naphtho[1,8-cd]isothiazole 1,1-dioxide | CHEMBL19051 |
Type | Small organic molecule |
Emp. Form. | C26H24FN3O2S |
Mol. Mass. | 461.551 |
SMILES | Fc1ccc2[nH]cc(CC3=CCN(CCN4c5cccc6cccc(c56)S4(=O)=O)CC3)c2c1 |t:9| |
Structure |
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