| Reaction Details |
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 | Report a problem with these data |
| Target | Type-1 angiotensin II receptor |
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| Ligand | BDBM50047111 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_36780 (CHEMBL650301) |
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| IC50 | 5±n/a nM |
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| Citation |  Bradbury, RH; Allott, CP; Dennis, M; Girdwood, JA; Kenny, PW; Major, JS; Oldham, AA; Ratcliffe, AH; Rivett, JE; Roberts, DA New nonpeptide angiotensin II receptor antagonists. 3. Synthesis, biological properties, and structure-activity relationships of 2-alkyl-4-(biphenylylmethoxy)pyridine derivatives. J Med Chem36:1245-54 (1993) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Type-1 angiotensin II receptor |
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| Name: | Type-1 angiotensin II receptor |
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| Synonyms: | AGTR1 | AGTR1_CAVPO | AT1 | Angiotensin II type-1 receptor |
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| Type: | PROTEIN |
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| Mol. Mass.: | 41004.19 |
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| Organism: | Cavia porcellus |
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| Description: | ChEMBL_36783 |
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| Residue: | 359 |
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| Sequence: | MILNSSTEDGIKRIQDDCPKAGRHSYIFVMIPTLYSIIFVVGIFGNSLVVIVIYFYMKLK
TVASVFLLNLALADICFLLTLPLWAVYTAMEYRWPFGNYLCKIASASVSFNLYASVFLLT
CLSIDRYLAIVHPMKSRLRRTMLVAKVTCVIIWLMAGLASLPAVIHRNVFFIENTNITVC
AFHYESQNSTLPIGLGLTKNILGFMFPFLIILTSYTLIWKALKKAYEIQKNKPRNDDIFK
IIMAIVLFFFFSWVPHQIFTFLDVLIQLGIIHDCKISDIVDTAMPITICIAYFNNCLNPL
FYGFLGKKFKKYFLQLLKYIPPKAKSHSTLSTKMSTLSYRPSDNVSSSAKKPVQCFEVE
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| BDBM50047111 |
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| n/a |
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| Name | BDBM50047111 |
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| Synonyms: | 6-Ethyl-2-methyl-4-[2'-(1H-tetrazol-5-yl)-biphenyl-4-ylmethoxy]-nicotinic acid methyl ester | CHEMBL283742 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H23N5O3 |
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| Mol. Mass. | 429.4711 |
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| SMILES | CCc1cc(OCc2ccc(cc2)-c2ccccc2-c2nnn[nH]2)c(C(=O)OC)c(C)n1 |
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| Structure | 
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