| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Adenosine receptor A2a/A2b |
|---|
| Ligand | BDBM50041576 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_30723 (CHEMBL648802) |
|---|
| Ki | 94±n/a nM |
|---|
| Citation |  Jacobson, KA; Gallo-Rodriguez, C; Melman, N; Fischer, B; Maillard, M; van Bergen, A; van Galen, PJ; Karton, Y Structure-activity relationships of 8-styrylxanthines as A2-selective adenosine antagonists. J Med Chem36:1333-42 (1993) [PubMed] |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Adenosine receptor A2a/A2b |
|---|
| Name: | Adenosine receptor A2a/A2b |
|---|
| Synonyms: | Adenosine A2 receptor |
|---|
| Type: | n/a |
|---|
| Mol. Mass.: | n/a |
|---|
| Description: | ASSAY_ID of ChEMBL is 30560 |
|---|
| Components: | This complex has 2 components. |
|---|
| Component 1 |
| Name: | Adenosine receptor A2b |
|---|
| Synonyms: | AA2BR_RAT | Adenosine receptor | Adora2b |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 36378.84 |
|---|
| Organism: | Rattus norvegicus |
|---|
| Description: | ChEMBL_32934 |
|---|
| Residue: | 332 |
|---|
| Sequence: | MQLETQDALYVALELVIAALAVAGNVLVCAAVGASSALQTPTNYFLVSLATADVAVGLFA
IPFAITISLGFCTDFHSCLFLACFVLVLTQSSIFSLLAVAVDRYLAIRVPLRYKGLVTGT
RARGIIAVLWVLAFGIGLTPFLGWNSKDRATSNCTEPGDGITNKSCCPVKCLFENVVPMS
YMVYFNFFGCVLPPLLIMMVIYIKIFMVACKQLQHMELMEHSRTTLQREIHAAKSLAMIV
GIFALCWLPVHAINCITLFHPALAKDKPKWVMNVAILLSHANSVVNPIVYAYRNRDFRYS
FHRIISRYVLCQTDTKGGSGQAGGQSTFSLSL
|
|
|
|---|
| Component 2 |
| Name: | Adenosine receptor A2a |
|---|
| Synonyms: | AA2AR_RAT | ADENOSINE A2a | Adenosine A2 receptor | Adenosine A2a receptor (A2a) | Adenosine Receptors A2a (A2a) | Adenosine receptor A2a and A3 | Adenosine receptors A2a | Adora2a | Rat striatal adenosine A2a receptor |
|---|
| Type: | G Protein-Coupled Receptor (GPCR) |
|---|
| Mol. Mass.: | 45015.65 |
|---|
| Organism: | Rattus norvegicus (rat) |
|---|
| Description: | Rat A2A receptors expressed in CHO cells. |
|---|
| Residue: | 410 |
|---|
| Sequence: | MGSSVYITVELAIAVLAILGNVLVCWAVWINSNLQNVTNFFVVSLAAADIAVGVLAIPFA
ITISTGFCAACHGCLFFACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGVRAKG
IIAICWVLSFAIGLTPMLGWNNCSQKDGNSTKTCGEGRVTCLFEDVVPMNYMVYYNFFAF
VLLPLLLMLAIYLRIFLAARRQLKQMESQPLPGERTRSTLQKEVHAAKSLAIIVGLFALC
WLPLHIINCFTFFCSTCRHAPPWLMYLAIILSHSNSVVNPFIYAYRIREFRQTFRKIIRT
HVLRRQEPFQAGGSSAWALAAHSTEGEQVSLRLNGHPLGVWANGSATHSGRRPNGYTLGL
GGGGSAQGSPRDVELPTQERQEGQEHPGLRGHLVQARVGASSWSSEFAPS
|
|
|
|---|
| BDBM50041576 |
|---|
| n/a |
|---|
| Name | BDBM50041576 |
|---|
| Synonyms: | 1,3,7-Trimethyl-8-((E)-styryl)-3,7-dihydro-purine-2,6-dione | 1,3,7-Trimethyl-8-styryl-3,7-dihydro-purine-2,6-dione | CHEMBL26897 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C16H16N4O2 |
|---|
| Mol. Mass. | 296.3238 |
|---|
| SMILES | Cn1c(\C=C\c2ccccc2)nc2n(C)c(=O)n(C)c(=O)c12 |
|---|
| Structure | 
|
|---|
Search and Browse
