| Reaction Details |
|---|
 | Report a problem with these data |
| Target | 5-hydroxytryptamine receptor 2A/2B/2C |
|---|
| Ligand | BDBM50047442 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_2136 (CHEMBL617219) |
|---|
| Ki | 3±n/a nM |
|---|
| Citation |  Mewshaw, RE; Silverman, LS; Mathew, RM; Kaiser, C; Sherrill, RG; Cheng, M; Tiffany, CW; Karbon, EW; Bailey, MA; Borosky, SA Bridged gamma-carbolines and derivatives possessing selective and combined affinity for 5-HT2 and D2 receptors. J Med Chem36:1488-95 (1993) [PubMed] |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| 5-hydroxytryptamine receptor 2A/2B/2C |
|---|
| Name: | 5-hydroxytryptamine receptor 2A/2B/2C |
|---|
| Synonyms: | Serotonin 2 (5-HT2) receptor |
|---|
| Type: | n/a |
|---|
| Mol. Mass.: | n/a |
|---|
| Description: | ASSAY_ID of ChEMBL is 2124 |
|---|
| Components: | This complex has 3 components. |
|---|
| Component 1 |
| Name: | 5-hydroxytryptamine receptor 2C |
|---|
| Synonyms: | 5-HT2C | 5-hydroxytryptamine receptor 2C | 5-hydroxytryptamine receptor 2C (5HT2C) | 5HT2C_MOUSE | 5ht1c | Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor | Htr1c | Htr2c | Serotonin 2c (5-HT2c) receptor |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 51948.16 |
|---|
| Organism: | Mus musculus (Mouse) |
|---|
| Description: | P34968 |
|---|
| Residue: | 459 |
|---|
| Sequence: | MVNLGTAVRSLLVHLIGLLVWQFDISISPVAAIVTDTFNSSDGGRLFQFPDGVQNWPALS
IVVIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYV
WPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVW
AISIGVSVPIPVIGLRDESKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYFLTIY
VLRRQTLMLLRGHTEEELRNISLNFLKCCCKKGDEEENAPNPNPDQKPRRKKKEKRPRGT
MQAINNEKKASKVLGIVFFVFLIMWCPFFITNILSVLCGKACNQKLMEKLLNVFVWIGYV
CSGINPLVYTLFNKIYRRAFSKYLRCDYKPDKKPPVRQIPRVAATALSGRELNVNIYRHT
NERVVRKANDTEPGIEMQVENLELPVNPSNVVSERISSV
|
|
|
|---|
| Component 2 |
| Name: | 5-hydroxytryptamine receptor 2A |
|---|
| Synonyms: | 5-HT-2 | 5-HT-2A | 5-hydroxytryptamine receptor 2A | 5-hydroxytryptamine receptor 2A (5HT2A) | 5HT2A_MOUSE | Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor | Htr2 | Htr2a | Serotonin 2a (5-HT2a) receptor |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 52843.00 |
|---|
| Organism: | Mus musculus (Mouse) |
|---|
| Description: | P35363 |
|---|
| Residue: | 471 |
|---|
| Sequence: | MEILCEDNISLSSIPNSLMQLGDDSRLYPNDFNSRDANTSEASNWTIDAENRTNLSCEGY
LPPTCLSILHLQEKNWSALLTTVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIAD
MLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNP
IHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSF
VAFFIPLTIMVITYFLTIKSLQKEATLCVSDLSTRAKLSSFSFLPQSSLSSEKLFQRSIH
REPGSYAGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNENVIGA
LLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENRKPLQLILVNTIPTLAYK
SSQLQVGQKKNSQEDAEPTANDCSMVTLGNQHSEEMCTDNIETVNEKVSCV
|
|
|
|---|
| Component 3 |
| Name: | 5-hydroxytryptamine receptor 2B |
|---|
| Synonyms: | 5-HT2 | 5-HT2B | 5-hydroxytryptamine receptor 2B | 5-hydroxytryptamine receptor 2B (5HT2B) | 5HT2B_MOUSE | Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor | Htr2b |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 53610.91 |
|---|
| Organism: | Mus musculus (Mouse) |
|---|
| Description: | Q02152 |
|---|
| Residue: | 479 |
|---|
| Sequence: | MASSYKMSEQSTTSEHILQKTCDHLILTNRSGLETDSVAEEMKQTVEGQGHTVHWAALLI
LAVIIPTIGGNILVILAVALEKRLQYATNYFLMSLAIADLLVGLFVMPIALLTIMFEAIW
PLPLALCPAWLFLDVLFSTASIMHLCAISLDRYIAIKKPIQANQCNSRATAFIKITVVWL
ISIGIAIPVPIKGIETDVINPHNVTCELTKDRFGSFMVFGSLAAFFAPLTIMVVTYFLTI
HTLQKKAYLVKNKPPQRLTRWTVPTVFLREDSSFSSPEKVAMLDGSHRDKILPNSSDETL
MRRMSSVGKRSAQTISNEQRASKALGVVFFLFLLMWCPFFITNLTLALCDSCNQTTLKTL
LEIFVWIGYVSSGVNPLIYTLFNKTFREAFGRYITCNYRATKSVKALRKFSSTLCFGNSM
VENSKFFTKHGIRNGINPAMYQSPMRLRSSTIQSSSIILLDTLLTENDGDKAEEQVSYI
|
|
|
|---|
| BDBM50047442 |
|---|
| n/a |
|---|
| Name | BDBM50047442 |
|---|
| Synonyms: | 5-[5-fluoro-9,15-diazatetracyclo[10.2.1.02,10.03,8]pentadeca-2(10),3,5,7-tetraen-15-yl]-1-phenyl-1-pentanone | CHEMBL37385 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C24H25FN2O |
|---|
| Mol. Mass. | 376.4665 |
|---|
| SMILES | Fc1ccc2[nH]c3CC4CCC(N4CCCCC(=O)c4ccccc4)c3c2c1 |TLB:13:12:25.6.7:10.9,26:25:12:10.9,5:6:12:10.9| |
|---|
| Structure | 
|
|---|
Search and Browse
