| Reaction Details |
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 | Report a problem with these data |
| Target | 5-hydroxytryptamine receptor 2A/2B/2C |
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| Ligand | BDBM50046475 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2136 (CHEMBL617219) |
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| Ki | 0.820000±n/a nM |
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| Citation |  Mewshaw, RE; Silverman, LS; Mathew, RM; Kaiser, C; Sherrill, RG; Cheng, M; Tiffany, CW; Karbon, EW; Bailey, MA; Borosky, SA Bridged gamma-carbolines and derivatives possessing selective and combined affinity for 5-HT2 and D2 receptors. J Med Chem36:1488-95 (1993) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| 5-hydroxytryptamine receptor 2A/2B/2C |
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| Name: | 5-hydroxytryptamine receptor 2A/2B/2C |
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| Synonyms: | Serotonin 2 (5-HT2) receptor |
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| Type: | n/a |
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| Mol. Mass.: | n/a |
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| Description: | ASSAY_ID of ChEMBL is 2124 |
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| Components: | This complex has 3 components. |
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| Component 1 |
| Name: | 5-hydroxytryptamine receptor 2C |
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| Synonyms: | 5-HT2C | 5-hydroxytryptamine receptor 2C | 5-hydroxytryptamine receptor 2C (5HT2C) | 5HT2C_MOUSE | 5ht1c | Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor | Htr1c | Htr2c | Serotonin 2c (5-HT2c) receptor |
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| Type: | Enzyme |
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| Mol. Mass.: | 51948.16 |
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| Organism: | Mus musculus (Mouse) |
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| Description: | P34968 |
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| Residue: | 459 |
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| Sequence: | MVNLGTAVRSLLVHLIGLLVWQFDISISPVAAIVTDTFNSSDGGRLFQFPDGVQNWPALS
IVVIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYV
WPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVW
AISIGVSVPIPVIGLRDESKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYFLTIY
VLRRQTLMLLRGHTEEELRNISLNFLKCCCKKGDEEENAPNPNPDQKPRRKKKEKRPRGT
MQAINNEKKASKVLGIVFFVFLIMWCPFFITNILSVLCGKACNQKLMEKLLNVFVWIGYV
CSGINPLVYTLFNKIYRRAFSKYLRCDYKPDKKPPVRQIPRVAATALSGRELNVNIYRHT
NERVVRKANDTEPGIEMQVENLELPVNPSNVVSERISSV
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| Component 2 |
| Name: | 5-hydroxytryptamine receptor 2A |
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| Synonyms: | 5-HT-2 | 5-HT-2A | 5-hydroxytryptamine receptor 2A | 5-hydroxytryptamine receptor 2A (5HT2A) | 5HT2A_MOUSE | Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor | Htr2 | Htr2a | Serotonin 2a (5-HT2a) receptor |
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| Type: | Enzyme |
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| Mol. Mass.: | 52843.00 |
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| Organism: | Mus musculus (Mouse) |
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| Description: | P35363 |
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| Residue: | 471 |
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| Sequence: | MEILCEDNISLSSIPNSLMQLGDDSRLYPNDFNSRDANTSEASNWTIDAENRTNLSCEGY
LPPTCLSILHLQEKNWSALLTTVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIAD
MLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNP
IHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSF
VAFFIPLTIMVITYFLTIKSLQKEATLCVSDLSTRAKLSSFSFLPQSSLSSEKLFQRSIH
REPGSYAGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNENVIGA
LLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENRKPLQLILVNTIPTLAYK
SSQLQVGQKKNSQEDAEPTANDCSMVTLGNQHSEEMCTDNIETVNEKVSCV
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| Component 3 |
| Name: | 5-hydroxytryptamine receptor 2B |
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| Synonyms: | 5-HT2 | 5-HT2B | 5-hydroxytryptamine receptor 2B | 5-hydroxytryptamine receptor 2B (5HT2B) | 5HT2B_MOUSE | Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor | Htr2b |
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| Type: | Enzyme |
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| Mol. Mass.: | 53610.91 |
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| Organism: | Mus musculus (Mouse) |
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| Description: | Q02152 |
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| Residue: | 479 |
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| Sequence: | MASSYKMSEQSTTSEHILQKTCDHLILTNRSGLETDSVAEEMKQTVEGQGHTVHWAALLI
LAVIIPTIGGNILVILAVALEKRLQYATNYFLMSLAIADLLVGLFVMPIALLTIMFEAIW
PLPLALCPAWLFLDVLFSTASIMHLCAISLDRYIAIKKPIQANQCNSRATAFIKITVVWL
ISIGIAIPVPIKGIETDVINPHNVTCELTKDRFGSFMVFGSLAAFFAPLTIMVVTYFLTI
HTLQKKAYLVKNKPPQRLTRWTVPTVFLREDSSFSSPEKVAMLDGSHRDKILPNSSDETL
MRRMSSVGKRSAQTISNEQRASKALGVVFFLFLLMWCPFFITNLTLALCDSCNQTTLKTL
LEIFVWIGYVSSGVNPLIYTLFNKTFREAFGRYITCNYRATKSVKALRKFSSTLCFGNSM
VENSKFFTKHGIRNGINPAMYQSPMRLRSSTIQSSSIILLDTLLTENDGDKAEEQVSYI
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| BDBM50046475 |
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| n/a |
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| Name | BDBM50046475 |
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| Synonyms: | 4-[9,15-diazatetracyclo[10.2.1.02,10.03,8]pentadeca-2(10),3,5,7-tetraen-15-yl]-1-(4-fluorophenyl)-1-butanone | CHEMBL36645 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H23FN2O |
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| Mol. Mass. | 362.4399 |
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| SMILES | Fc1ccc(cc1)C(=O)CCCN1C2CCC1c1c(C2)[nH]c2ccccc12 |TLB:11:12:17.18.19:15.14,THB:20:18:12:15.14,26:17:12:15.14| |
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| Structure | 
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