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TargetAcyl-CoA:cholesterol acyltransferase
LigandBDBM50047525
Substrate/Competitorn/a
Meas. Tech.ChEMBL_28333 (CHEMBL645897)
IC50 17±n/a nM
Citation Kimura, TTakase, YHayashi, KTanaka, HOhtsuka, ISaeki, TKogushi, MYamada, TFujimori, TSaitou, I Structure-activity relationship of N-[2-(dimethylamino)-6-[3-(5-methyl-4-phenyl-1H-imidazol-1-yl)propoxy] phenyl]-N'-pentylurea and analogues. Novel potent inhibitors of acyl-CoA:cholesterol O-acyltransferase with antiatherosclerotic activity. J Med Chem36:1630-40 (1993) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
Acyl-CoA:cholesterol acyltransferase
Name:Acyl-CoA:cholesterol acyltransferase
Synonyms:ACAT
Type:n/a
Mol. Mass.:35405.31
Organism:Oryctolagus cuniculus
Description:n/a
Residue:305
Sequence:
PLFLKEVGSHFDDFVTNLIEKSASLDNGGCALTTFSILKEMKNNHRAKDLRAPPEQGKIF
VARRSLLDELFEVDHIRTIYHMFIALLILFILSTLVVDYIDEGRLVLEFNLLSYAFGKLP
TVVWTWWTMFLSTLSIPYFLFQHWANGYSKSSHPLMYSLFHGLLFMVFQLGILGFGPTYI
VLAYTLPPASRFIVILEQIRLIMKAHSFVRENVPRVLNSAKEKSSTVPIPTVNQYLYFLF
APTLIYRDSYPRTPTVRWGYVAMQFAQVFGCLFYVYYIFERLCAPLFRNIKQEPFSARVL
VLCIF
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50047525
n/a
NameBDBM50047525
Synonyms:1-{2-Dimethylamino-6-[3-(4-phenyl-piperazin-1-yl)-propoxy]-phenyl}-3-pentyl-urea | CHEMBL42166
TypeSmall organic molecule
Emp. Form.C27H41N5O2
Mol. Mass.467.6467
SMILESCCCCCNC(=O)Nc1c(OCCCN2CCN(CC2)c2ccccc2)cccc1N(C)C
Structure
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