| Reaction Details |
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 | Report a problem with these data |
| Target | cGMP-dependent 3',5'-cyclic phosphodiesterase |
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| Ligand | BDBM50048241 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_156307 (CHEMBL762540) |
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| Ki | >100000±n/a nM |
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| Citation |  Stafford, JA; Veal, JM; Feldman, PL; Valvano, NL; Baer, PG; Brackeen, MF; Brawley, ES; Connolly, KM; Domanico, PL; Han, B Introduction of a conformational switching element on a pyrrolidine ring. Synthesis and evaluation of (R*,R*)-(+/-)-methyl 3-acetyl-4-[3- (cyclopentyloxy)-4-methoxyphenyl]-3-methyl-1-pyrrolidinecarboxylate, a potent and selective inhibitor of cAMP-specific phosphodiesterase. J Med Chem38:4972-5 (1996) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| cGMP-dependent 3',5'-cyclic phosphodiesterase |
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| Name: | cGMP-dependent 3',5'-cyclic phosphodiesterase |
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| Synonyms: | PDE2A | PDE2A_BOVIN | Phosphodiesterase 2A |
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| Type: | PROTEIN |
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| Mol. Mass.: | 103200.18 |
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| Organism: | Bos taurus |
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| Description: | ChEMBL_154420 |
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| Residue: | 921 |
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| Sequence: | MRRQPAASRDLFAQEPVPPGSGDGALQDALLSLGSVIDVAGLQQAVKEALSAVLPKVETV
YTYLLDGESRLVCEEPPHELPQEGKVREAVISRKRLGCNGLGPSDLPGKPLARLVAPLAP
DTQVLVIPLVDKEAGAVAAVILVHCGQLSDNEEWSLQAVEKHTLVALKRVQALQQRESSV
APEATQNPPEEAAGDQKGGVAYTNQDRKILQLCGELYDLDASSLQLKVLQYLQQETQASR
CCLLLVSEDNLQLSCKVIGDKVLEEEISFPLTTGRLGQVVEDKKSIQLKDLTSEDMQQLQ
SMLGCEVQAMLCVPVISRATDQVVALACAFNKLGGDLFTDQDEHVIQHCFHYTSTVLTST
LAFQKEQKLKCECQALLQVAKNLFTHLDDVSVLLQEIITEARNLSNAEICSVFLLDQNEL
VAKVFDGGVVEDESYEIRIPADQGIAGHVATTGQILNIPDAYAHPLFYRGVDDSTGFRTR
NILCFPIKNENQEVIGVAELVNKINGPWFSKFDEDLATAFSIYCGISIAHSLLYKKVNEA
QYRSHLANEMMMYHMKVSDDEYTKLLHDGIQPVAAIDSNFASFTYTPRSLPEDDTSMAIL
SMLQDMNFINNYKIDCPTLARFCLMVKKGYRDPPYHNWMHAFSVSHFCYLLYKNLELTNY
LEDMEIFALFISCMCHDLDHRGTNNSFQVASKSVLAALYSSEGSVMERHHFAQAIAILNT
HGCNIFDHFSRKDYQRMLDLMRDIILATDLAHHLRIFKDLQKMAEVGYDRTNKQHHSLLL
CLLMTSCDLSDQTKGWKTTRKIAELIYKEFFSQGDLEKAMGNRPMEMMDREKAYIPELQI
SFMEHIAMPIYKLLQDLFPKAAELYERVASNREHWTKVSHKFTIRGLPSNNSLDFLDEEY
EVPDLDGARAPINGCCSLDAE
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| BDBM50048241 |
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| n/a |
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| Name | BDBM50048241 |
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| Synonyms: | (3S,4S)-3-Acetyl-4-(3-cyclopentyloxy-4-methoxy-phenyl)-3-methyl-pyrrolidine-1-carboxylic acid methyl ester | CHEMBL344944 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H29NO5 |
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| Mol. Mass. | 375.4587 |
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| SMILES | COC(=O)N1C[C@@H](c2ccc(OC)c(OC3CCCC3)c2)[C@@](C)(C1)C(C)=O |
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| Structure | 
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