Reaction Details |
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Target | Neprilysin |
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Ligand | BDBM50048512 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_144479 (CHEMBL754638) |
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IC50 | 6±n/a nM |
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Citation | Robl, JA; Cimarusti, MP; Simpkins, LM; Brown, B; Ryono, DE; Bird, JE; Asaad, MM; Schaeffer, TR; Trippodo, NC Dual metalloprotease inhibitors. 6. Incorporation of bicyclic and substituted monocyclic azepinones as dipeptide surrogates in angiotensin-converting enzyme/neutral endopeptidase inhibitors. J Med Chem39:494-502 (1996) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Neprilysin |
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Name: | Neprilysin |
Synonyms: | Mme | NEP_RAT | Neprilysin | Neutral Endopeptidase (NEP) | Neutral endopeptidase 24.11 |
Type: | Protein |
Mol. Mass.: | 85789.59 |
Organism: | Rattus norvegicus (Rat) |
Description: | P07861 |
Residue: | 750 |
Sequence: | MGRSESQMDITDINAPKPKKKQRWTPLEISLSVLVLLLTIIAVTMIALYATYDDGICKSS
DCIKSAARLIQNMDASAEPCTDFFKYACGGWLKRNVIPETSSRYSNFDILRDELEVILKD
VLQEPKTEDIVAVQKAKTLYRSCINESAIDSRGGQPLLTLLPDIYGWPVASQNWEQTYGT
SWTAEKSIAQLNSKYGKKVLINFFVGTDDKNSTQHIIHFDQPRLGLPSRDYYECTGIYKE
ACTAYVDFMISVARLIRQEQRLPIDENQLSLEMNKVMELEKEIANATTKPEDRNDPMLLY
NKMTLAKLQNNFSLEINGKPFSWSNFTNEIMSTVNINIQNEEEVVVYAPEYLTKLKPILT
KYSPRDLQNLMSWRFIMDLVSSLSRNYKESRNAFRKALYGTTSETATWRRCANYVNGNME
NAVGRLYVEAAFAGESKHVVEDLIAQIREVFIQTLDDLTWMDAETKKKAEEKALAIKERI
GYPDDIISNENKLNNEYLELNYKEEEYFENIIQNLKFSQSKQLKKLREKVDKDEWISGAA
VVNAFYSSGRNQIVFPAGILQPPFFSARQSNSLNYGGIGMVIGHEITHGFDDNGRNFNKD
GDLVDWWTQQSANNFKDQSQCMVYQYGNFTWDLAGGQHLNGINTLGENIADNGGIGQAYR
AYQNYVKKNGEEKLLPGLDLNHKQLFFLNFAQVWCGTYRPEYAVNSIKTDVHSPGNFRII
GTLQNSAEFADAFHCRKNSYMNPERKCRVW
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BDBM50048512 |
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n/a |
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Name | BDBM50048512 |
Synonyms: | CHEMBL299639 | [(S)-3-((S)-2-Mercapto-3-phenyl-propionylamino)-2-oxo-2,3,4,5-tetrahydro-benzo[b]azepin-1-yl]-acetic acid | [3-((S)-2-Mercapto-3-(S)-phenyl-propionylamino)-2-oxo-2,3,4,5-tetrahydro-benzo[b]azepin-1-yl]-acetic acid |
Type | Small organic molecule |
Emp. Form. | C21H22N2O4S |
Mol. Mass. | 398.475 |
SMILES | OC(=O)CN1c2ccccc2CC[C@H](NC(=O)[C@@H](S)Cc2ccccc2)C1=O |
Structure |
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