| Reaction Details |
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 | Report a problem with these data |
| Target | Peroxisome proliferator-activated receptor gamma |
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| Ligand | BDBM50049244 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_154537 (CHEMBL760257) |
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| EC50 | 13±n/a nM |
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| Citation |  Willson, TM; Cobb, JE; Cowan, DJ; Wiethe, RW; Correa, ID; Prakash, SR; Beck, KD; Moore, LB; Kliewer, SA; Lehmann, JM The structure-activity relationship between peroxisome proliferator-activated receptor gamma agonism and the antihyperglycemic activity of thiazolidinediones. J Med Chem39:665-8 (1996) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Peroxisome proliferator-activated receptor gamma |
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| Name: | Peroxisome proliferator-activated receptor gamma |
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| Synonyms: | Nr1c3 | Nuclear receptor subfamily 1 group C member 3 | PPAR-gamma | PPARG_MOUSE | Pparg |
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| Type: | PROTEIN |
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| Mol. Mass.: | 57593.55 |
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| Organism: | Mus musculus |
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| Description: | ChEMBL_1453700 |
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| Residue: | 505 |
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| Sequence: | MGETLGDSPVDPEHGAFADALPMSTSQEITMVDTEMPFWPTNFGISSVDLSVMEDHSHSF
DIKPFTTVDFSSISAPHYEDIPFTRADPMVADYKYDLKLQEYQSAIKVEPASPPYYSEKT
QLYNRPHEEPSNSLMAIECRVCGDKASGFHYGVHACEGCKGFFRRTIRLKLIYDRCDLNC
RIHKKSRNKCQYCRFQKCLAVGMSHNAIRFGRMPQAEKEKLLAEISSDIDQLNPESADLR
ALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLMMGEDKIKFKHITPLQE
QSKEVAIRIFQGCQFRSVEAVQEITEYAKNIPGFINLDLNDQVTLLKYGVHEIIYTMLAS
LMNKDGVLISEGQGFMTREFLKNLRKPFGDFMEPKFEFAVKFNALELDDSDLAIFIAVII
LSGDRPGLLNVKPIEDIQDNLLQALELQLKLNHPESSQLFAKVLQKMTDLRQIVTEHVQL
LHVIKKTETDMSLHPLLQEIYKDLY
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| BDBM50049244 |
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| n/a |
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| Name | BDBM50049244 |
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| Synonyms: | 5-{4-[2-(Benzooxazol-2-yl-methyl-amino)-ethoxy]-benzyl}-thiazolidine-2,4-dione | BRL-48482 | CHEMBL17805 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H19N3O4S |
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| Mol. Mass. | 397.448 |
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| SMILES | CN(CCOc1ccc(Cc2sc(=O)[nH]c2O)cc1)c1nc2ccccc2o1 |
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| Structure | 
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