| Reaction Details |
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 | Report a problem with these data |
| Target | Peroxisome proliferator-activated receptor gamma |
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| Ligand | BDBM50049246 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_154537 |
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| EC50 | 13000±n/a nM |
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| Citation |  Willson TM; Cobb JE; Cowan DJ; Wiethe RW; Correa ID; Prakash SR; Beck KD; Moore LB; Kliewer SA; Lehmann JM The structure-activity relationship between peroxisome proliferator-activated receptor gamma agonism and the antihyperglycemic activity of thiazolidinediones. J Med Chem 39:665-8 (1996) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Peroxisome proliferator-activated receptor gamma |
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| Name: | Peroxisome proliferator-activated receptor gamma |
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| Synonyms: | Nuclear receptor subfamily 1 group C member 3 | PPAR-gamma |
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| Type: | PROTEIN |
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| Mol. Mass.: | 57593.55 |
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| Organism: | Mus musculus |
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| Description: | ChEMBL_1453700 |
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| Residue: | 505 |
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| Sequence: | MGETLGDSPVDPEHGAFADALPMSTSQEITMVDTEMPFWPTNFGISSVDLSVMEDHSHSF
DIKPFTTVDFSSISAPHYEDIPFTRADPMVADYKYDLKLQEYQSAIKVEPASPPYYSEKT
QLYNRPHEEPSNSLMAIECRVCGDKASGFHYGVHACEGCKGFFRRTIRLKLIYDRCDLNC
RIHKKSRNKCQYCRFQKCLAVGMSHNAIRFGRMPQAEKEKLLAEISSDIDQLNPESADLR
ALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLMMGEDKIKFKHITPLQE
QSKEVAIRIFQGCQFRSVEAVQEITEYAKNIPGFINLDLNDQVTLLKYGVHEIIYTMLAS
LMNKDGVLISEGQGFMTREFLKNLRKPFGDFMEPKFEFAVKFNALELDDSDLAIFIAVII
LSGDRPGLLNVKPIEDIQDNLLQALELQLKLNHPESSQLFAKVLQKMTDLRQIVTEHVQL
LHVIKKTETDMSLHPLLQEIYKDLY
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| BDBM50049246 |
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| n/a |
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| Name | BDBM50049246 |
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| Synonyms: | 5-((R)-2-Benzyl-chroman-6-ylmethyl)-thiazolidine-2,4-dione | CHEMBL17669 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H19NO3S |
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| Mol. Mass. | 353.435 |
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| SMILES | Oc1[nH]c(=O)sc1Cc1ccc2O[C@@H](Cc3ccccc3)CCc2c1 |
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| Structure | 
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