| Reaction Details |
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 | Report a problem with these data |
| Target | DNA topoisomerase 1 |
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| Ligand | BDBM50049293 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_53713 (CHEMBL663641) |
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| IC50 | 250±n/a nM |
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| Citation |  Lackey, K; Sternbach, DD; Croom, DK; Emerson, DL; Evans, MG; Leitner, PL; Luzzio, MJ; McIntyre, G; Vuong, A; Yates, J; Besterman, JM Water soluble inhibitors of topoisomerase I: quaternary salt derivatives of camptothecin. J Med Chem39:713-9 (1996) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| DNA topoisomerase 1 |
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| Name: | DNA topoisomerase 1 |
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| Synonyms: | DNA topoisomerase I | DNA topoisomerase I (Topo I) | TOP1 | TOP1_HUMAN |
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| Type: | Enzyme |
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| Mol. Mass.: | 90771.02 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P11387 |
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| Residue: | 765 |
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| Sequence: | MSGDHLHNDSQIEADFRLNDSHKHKDKHKDREHRHKEHKKEKDREKSKHSNSEHKDSEKK
HKEKEKTKHKDGSSEKHKDKHKDRDKEKRKEEKVRASGDAKIKKEKENGFSSPPQIKDEP
EDDGYFVPPKEDIKPLKRPRDEDDADYKPKKIKTEDTKKEKKRKLEEEEDGKLKKPKNKD
KDKKVPEPDNKKKKPKKEEEQKWKWWEEERYPEGIKWKFLEHKGPVFAPPYEPLPENVKF
YYDGKVMKLSPKAEEVATFFAKMLDHEYTTKEIFRKNFFKDWRKEMTNEEKNIITNLSKC
DFTQMSQYFKAQTEARKQMSKEEKLKIKEENEKLLKEYGFCIMDNHKERIANFKIEPPGL
FRGRGNHPKMGMLKRRIMPEDIIINCSKDAKVPSPPPGHKWKEVRHDNKVTWLVSWTENI
QGSIKYIMLNPSSRIKGEKDWQKYETARRLKKCVDKIRNQYREDWKSKEMKVRQRAVALY
FIDKLALRAGNEKEEGETADTVGCCSLRVEHINLHPELDGQEYVVEFDFLGKDSIRYYNK
VPVEKRVFKNLQLFMENKQPEDDLFDRLNTGILNKHLQDLMEGLTAKVFRTYNASITLQQ
QLKELTAPDENIPAKILSYNRANRAVAILCNHQRAPPKTFEKSMMNLQTKIDAKKEQLAD
ARRDLKSAKADAKVMKDAKTKKVVESKKKAVQRLEEQLMKLEVQATDREENKQIALGTSK
LNYLDPRITVAWCKKWGVPIEKIYNKTQREKFAWAIDMADEDYEF
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| BDBM50049293 |
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| n/a |
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| Name | BDBM50049293 |
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| Synonyms: | 8-ethyl-8-hydroxy-15-pyridazin-1-ium-1-ylmethyl-(8S)-2,3,8,9,12,14-hexahydro-11H-[1,4]dioxino[3,2-g]pyrano[3',4':6,7]indolizino[1,2-b]quinoline-9,12-dione | CHEMBL163162 |
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| Type | Small organic molecule |
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| Emp. Form. | C27H23N4O6 |
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| Mol. Mass. | 499.4942 |
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| SMILES | CC[C@@]1(O)C(=O)OCc2c1cc1-c3nc4cc5OCCOc5cc4c(C[n+]4ccccn4)c3Cn1c2=O |
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| Structure | 
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