| Reaction Details |
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 | Report a problem with these data |
| Target | Substance-P receptor |
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| Ligand | BDBM50049338 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_205413 (CHEMBL812236) |
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| IC50 | 0.880000±n/a nM |
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| Citation |  Hipskind, PA; Howbert, JJ; Bruns, RF; Cho, SS; Crowell, TA; Foreman, MM; Gehlert, DR; Iyengar, S; Johnson, KW; Krushinski, JH; Li, DL; Lobb, KL; Mason, NR; Muehl, BS; Nixon, JA; Phebus, LA; Regoli, D; Simmons, RM; Threlkeld, PG; Waters, DC; Gitter, BD 3-Aryl-1,2-diacetamidopropane derivatives as novel and potent NK-1 receptor antagonists. J Med Chem39:736-48 (1996) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Substance-P receptor |
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| Name: | Substance-P receptor |
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| Synonyms: | NK1R_CAVPO | Neurokinin 1 receptor | Neurokinin NK1 | TAC1R | TACR1 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 46261.42 |
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| Organism: | GUINEA PIG |
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| Description: | Neurokinin NK1 TACR1 GUINEA PIG::P30547 |
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| Residue: | 407 |
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| Sequence: | MDNVLPVDSDLFPNISTNTSEPNQFVQPAWQIVLWAAAYTVIVVTSVVGNVVVMWIILAH
KRMRTVTNYFLVNLAFAEASMAAFNTVVNFTYAVHNEWYYGLFYCKFHNFFPIAAVFASI
YSMTAVAFDRYMAIIHPLQPRLSATATKVVICVIWVLALLLAFPQGYYSTTETMPGRVVC
MIEWPSHPDKIYEKVYHICVTVLIYFLPLLVIGYAYTVVGITLWASEIPGDSSDRYHEQV
SAKRKVVKMMIVVVCTFAICWLPFHIFFLLPYINPDLYLKKFIQQVYLAIMWLAMSSTMY
NPIIYCCLNDRFRLGFKHAFRCCPFISAADYEGLEMKSTRYFQTQGSVYKVSRLETTIST
VVGAHEEDPEEGPKATPSSLDLTSNGSSRSNSKTVTESSSFYSNMLS
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| BDBM50049338 |
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| n/a |
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| Name | BDBM50049338 |
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| Synonyms: | CHEMBL353093 | N-[1-{[Acetyl-(2-methoxy-benzyl)-amino]-methyl}-2-(1H-indol-3-yl)-ethyl]-2-(4-benzyl-piperazin-1-yl)-acetamide |
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| Type | Small organic molecule |
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| Emp. Form. | C34H41N5O3 |
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| Mol. Mass. | 567.721 |
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| SMILES | COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(Cc2ccccc2)CC1)C(C)=O |
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| Structure | 
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