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Reaction Details
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TargetSubstance-P receptor
LigandBDBM50049335
Substrate/Competitorn/a
Meas. Tech.ChEMBL_205731 (CHEMBL809498)
IC50 3±n/a nM
Citation Hipskind, PAHowbert, JJBruns, RFCho, SSCrowell, TAForeman, MMGehlert, DRIyengar, SJohnson, KWKrushinski, JHLi, DLLobb, KLMason, NRMuehl, BSNixon, JAPhebus, LARegoli, DSimmons, RMThrelkeld, PGWaters, DCGitter, BD 3-Aryl-1,2-diacetamidopropane derivatives as novel and potent NK-1 receptor antagonists. J Med Chem39:736-48 (1996) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Substance-P receptor
Name:Substance-P receptor
Synonyms:NK-1 receptor | NK-1R | NK1 Receptor | NK1R | NK1R_HUMAN | Neurokinin 1 receptor | Neurokinin-1 (NK-1) | Neuromedin-1 receptor (NK-1R) | SPR | TAC1R | TACR1 | Tachykinin receptor 1 | Tachykinin receptor 1 (NK1) | tachykinin
Type:G Protein-Coupled Receptor (GPCR)
Mol. Mass.:46254.43
Organism:Homo sapiens (Human)
Description:P25103
Residue:407
Sequence:
MDNVLPVDSDLSPNISTNTSEPNQFVQPAWQIVLWAAAYTVIVVTSVVGNVVVMWIILAH
KRMRTVTNYFLVNLAFAEASMAAFNTVVNFTYAVHNEWYYGLFYCKFHNFFPIAAVFASI
YSMTAVAFDRYMAIIHPLQPRLSATATKVVICVIWVLALLLAFPQGYYSTTETMPSRVVC
MIEWPEHPNKIYEKVYHICVTVLIYFLPLLVIGYAYTVVGITLWASEIPGDSSDRYHEQV
SAKRKVVKMMIVVVCTFAICWLPFHIFFLLPYINPDLYLKKFIQQVYLAIMWLAMSSTMY
NPIIYCCLNDRFRLGFKHAFRCCPFISAGDYEGLEMKSTRYLQTQGSVYKVSRLETTIST
VVGAHEEEPEDGPKATPSSLDLTSNCSSRSDSKTMTESFSFSSNVLS
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  Blast E-value cutoff:
BDBM50049335
n/a
NameBDBM50049335
Synonyms:CHEMBL165510 | N-{2-(1H-Indol-3-yl)-1-[1-(2-methoxy-benzyl)-3-methyl-ureidomethyl]-ethyl}-2-(4-phenyl-piperazin-1-yl)-acetamide
TypeSmall organic molecule
Emp. Form.C33H40N6O3
Mol. Mass.568.7091
SMILESCNC(=O)N(CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(CC1)c1ccccc1)Cc1ccccc1OC
Structure
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