Reaction Details |
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Target | Substance-K receptor |
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Ligand | BDBM50049469 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_209020 (CHEMBL816315) |
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IC50 | 7±n/a nM |
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Citation | Hale, JJ; Mills, SG; MacCoss, M; Shah, SK; Qi, H; Mathre, DJ; Cascieri, MA; Sadowski, S; Strader, CD; MacIntyre, DE; Metzger, JM 2(S)-((3,5-bis(trifluoromethyl)benzyl)-oxy)-3(S)-phenyl-4- ((3-oxo-1,2,4-triazol-5-yl)methyl)morpholine (1): a potent, orally active, morpholine-based human neurokinin-1 receptor antagonist. J Med Chem39:1760-2 (1996) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Substance-K receptor |
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Name: | Substance-K receptor |
Synonyms: | NK-2 receptor | NK-2R | NK2R | NK2R_HUMAN | NKNAR | Neurokinin 2 receptor | Neurokinin A receptor | Neurokinin NK2 | Neurokinin-2 (NK-2) | Neuromedin-2 receptor (NK-2R) | SKR | TAC2R | TACR2 | Tachykinin receptor 2 | Tachykinin receptor 2 (NK2) | hnk-3 |
Type: | Protein |
Mol. Mass.: | 44455.78 |
Organism: | Homo sapiens (Human) |
Description: | P21452 |
Residue: | 398 |
Sequence: | MGTCDIVTEANISSGPESNTTGITAFSMPSWQLALWATAYLALVLVAVTGNAIVIWIILA
HRRMRTVTNYFIVNLALADLCMAAFNAAFNFVYASHNIWYFGRAFCYFQNLFPITAMFVS
IYSMTAIAADRYMAIVHPFQPRLSAPSTKAVIAGIWLVALALASPQCFYSTVTMDQGATK
CVVAWPEDSGGKTLLLYHLVVIALIYFLPLAVMFVAYSVIGLTLWRRAVPGHQAHGANLR
HLQAMKKFVKTMVLVVLTFAICWLPYHLYFILGSFQEDIYCHKFIQQVYLALFWLAMSST
MYNPIIYCCLNHRFRSGFRLAFRCCPWVTPTKEDKLELTPTTSLSTRVNRCHTKETLFMA
GDTAPSEATSGEAGRPQDGSGLWFGYGLLAPTKTHVEI
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BDBM50049469 |
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n/a |
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Name | BDBM50049469 |
Synonyms: | 5-(((2S,3S)-2-(3,5-bis(trifluoromethyl)benzyloxy)-3-phenylmorpholino)methyl)-2H-1,2,4-triazol-3(4H)-one | 5-[(2S,3S)-2-(3,5-Bis-trifluoromethyl-benzyloxy)-3-phenyl-morpholin-4-ylmethyl]-2,4-dihydro-[1,2,4]triazol-3-one | CHEMBL52330 |
Type | Small organic molecule |
Emp. Form. | C22H20F6N4O3 |
Mol. Mass. | 502.4096 |
SMILES | FC(F)(F)c1cc(CO[C@H]2OCCN(Cc3n[nH]c(=O)[nH]3)[C@H]2c2ccccc2)cc(c1)C(F)(F)F |r| |
Structure |
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