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TargetDihydrofolate reductase
LigandBDBM18224
Substrate/Competitorn/a
Meas. Tech.ChEMBL_52843 (CHEMBL665047)
IC50 31±n/a nM
Citation Gangjee, AZhu, YQueener, SFFrancom, PBroom, AD Nonclassical 2,4-diamino-8-deazafolate analogues as inhibitors of dihydrofolate reductases from rat liver, Pneumocystis carinii, and Toxoplasma gondii. J Med Chem39:1836-45 (1996) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Dihydrofolate reductase
Name:Dihydrofolate reductase
Synonyms:DFR1 | DYR_YEAST
Type:PROTEIN
Mol. Mass.:24263.24
Organism:Saccharomyces cerevisiae
Description:ChEMBL_52843
Residue:211
Sequence:
MAGGKIPIVGIVACLQPEMGIGFRGGLPWRLPSEMKYFRQVTSLTKDPNKKNALIMGRKT
WESIPPKFRPLPNRMNVIISRSFKDDFVHDKERSIVQSNSLANAIMNLESNFKEHLERIY
VIGGGEVYSQIFSITDHWLITKINPLDKNATPAMDTFLDAKKLEEVFSEQDPAQLKEFLP
PKVELPETDCDQRYSLEEKGYCFEFTLYNRK
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  Blast E-value cutoff:
BDBM18224
n/a
NameBDBM18224
Synonyms:6-[(2,5-dimethoxyphenyl)methyl]-5-methylpyrido[2,3-d]pyrimidine-2,4-diamine | CHEMBL7492 | PTX | Piritrexim | [2-amino-6-(2,5-dimethoxybenzyl)-5-methyl-pyrido[2,3-d]pyrimidin-4-yl]amine;2-hydroxyethanesulfonic acid
TypeSmall organic molecule
Emp. Form.C17H19N5O2
Mol. Mass.325.3651
SMILESCOc1ccc(OC)c(Cc2cnc3nc(N)nc(N)c3c2C)c1
Structure
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