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TargetDihydrofolate reductase
LigandBDBM50049897
Substrate/Competitorn/a
Meas. Tech.ChEMBL_54280
Ki 0.2±n/a nM
Citation Kuyper LFBaccanari DPJones MLHunter RNTansik RLJoyner SSBoytos CMRudolph SKKnick VWilson HRCaddell JMFriedman HSComley JCStables JN High-affinity inhibitors of dihydrofolate reductase: antimicrobial and anticancer activities of 7,8-dialkyl-1,3-diaminopyrrolo[3,2-f]quinazolines with small molecular size. J Med Chem 39:892-903 (1996) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Dihydrofolate reductase
Name:Dihydrofolate reductase
Synonyms:Dihydrofolate reductase (DHFR) | Tetrahydrofolate dehydrogenase
Type:Enzyme
Mol. Mass.:21453.99
Organism:Homo sapiens (Human)
Description:Recombinant human DHFR.
Residue:187
Sequence:
MVGSLNCIVAVSQNMGIGKNGDLPWPPLRNEFRYFQRMTTTSSVEGKQNLVIMGKKTWFS
IPEKNRPLKGRINLVLSRELKEPPQGAHFLSRSLDDALKLTEQPELANKVDMVWIVGGSS
VYKEAMNHPGHLKLFVTRIMQDFESDTFFPEIDLEKYKLLPEYPGVLSDVQEEKGIKYKF
EVYEKND
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BDBM50049897
n/a
NameBDBM50049897
Synonyms:8-Ethyl-7-(1-ethyl-propyl)-7H-pyrrolo[3,2-f]quinazoline-1,3-diamine | CHEMBL352960 | TCMDC-137309
TypeSmall organic molecule
Emp. Form.C17H23N5
Mol. Mass.297.398
SMILESCCC(CC)n1c(CC)cc2c1ccc1nc(N)nc(N)c21
Structure
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