| Reaction Details |
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 | Report a problem with these data |
| Target | Dihydrofolate reductase |
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| Ligand | BDBM50049914 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_54223 (CHEMBL668101) |
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| Ki | 0.23±n/a nM |
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| Citation |  Kuyper, LF; Baccanari, DP; Jones, ML; Hunter, RN; Tansik, RL; Joyner, SS; Boytos, CM; Rudolph, SK; Knick, V; Wilson, HR; Caddell, JM; Friedman, HS; Comley, JC; Stables, JN High-affinity inhibitors of dihydrofolate reductase: antimicrobial and anticancer activities of 7,8-dialkyl-1,3-diaminopyrrolo[3,2-f]quinazolines with small molecular size. J Med Chem39:892-903 (1996) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Dihydrofolate reductase |
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| Name: | Dihydrofolate reductase |
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| Synonyms: | DFR1 | DYR_CANAX | Dihydrofolate Reductase (DHFR) | Tetrahydrofolate dehydrogenase |
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| Type: | Enzyme |
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| Mol. Mass.: | 22141.77 |
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| Organism: | Candida albicans |
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| Description: | C. albicans DHFR was expressed in E. coli BL21, and purified to homogeneity. |
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| Residue: | 192 |
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| Sequence: | MSKPNVAIIVAALKPALGIGYKGKMPWRLRKEIRYFKDVTTRTTKPNTRNAVIMGRKTWE
SIPQKFRPLPDRLNIILSRSYENKIIDDNIIHASSIESSLNLVSDVERVFIIGGAEIYNE
LINNSLVSHLLITEIEHPSPESIEMDTFLKFPLESWTKQPKSELQKFVGDTVLEDDIKEG
DFTYNYTLWTRK
|
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| BDBM50049914 |
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| n/a |
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| Name | BDBM50049914 |
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| Synonyms: | 7-(3,4,5-Trimethoxy-benzyl)-7H-pyrrolo[3,2-f]quinazoline-1,3-diamine | CHEMBL353621 | TCMDC-137341 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H21N5O3 |
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| Mol. Mass. | 379.4124 |
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| SMILES | COc1cc(Cn2ccc3c2ccc2nc(N)nc(N)c32)cc(OC)c1OC |
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| Structure | 
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