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TargetDihydrofolate reductase
LigandBDBM50049915
Substrate/Competitorn/a
Meas. Tech.ChEMBL_54280 (CHEMBL669873)
Ki 29±n/a nM
Citation Kuyper, LFBaccanari, DPJones, MLHunter, RNTansik, RLJoyner, SSBoytos, CMRudolph, SKKnick, VWilson, HRCaddell, JMFriedman, HSComley, JCStables, JN High-affinity inhibitors of dihydrofolate reductase: antimicrobial and anticancer activities of 7,8-dialkyl-1,3-diaminopyrrolo[3,2-f]quinazolines with small molecular size. J Med Chem39:892-903 (1996) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Dihydrofolate reductase
Name:Dihydrofolate reductase
Synonyms:DHFR | DYR_HUMAN | Dihydrofolate reductase (DHFR) | Tetrahydrofolate dehydrogenase
Type:Enzyme
Mol. Mass.:21453.99
Organism:Homo sapiens (Human)
Description:Recombinant human DHFR.
Residue:187
Sequence:
MVGSLNCIVAVSQNMGIGKNGDLPWPPLRNEFRYFQRMTTTSSVEGKQNLVIMGKKTWFS
IPEKNRPLKGRINLVLSRELKEPPQGAHFLSRSLDDALKLTEQPELANKVDMVWIVGGSS
VYKEAMNHPGHLKLFVTRIMQDFESDTFFPEIDLEKYKLLPEYPGVLSDVQEEKGIKYKF
EVYEKND
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  Blast E-value cutoff:
BDBM50049915
n/a
NameBDBM50049915
Synonyms:8-Ethyl-7-methyl-7H-pyrrolo[3,2-f]quinazoline-1,3-diamine | CHEMBL170900
TypeSmall organic molecule
Emp. Form.C13H15N5
Mol. Mass.241.2917
SMILESCCc1cc2c(ccc3nc(N)nc(N)c23)n1C
Structure
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