Reaction Details |
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Target | Endothelin-1 receptor |
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Ligand | BDBM50050063 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_65491 (CHEMBL682366) |
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IC50 | 4.6±n/a nM |
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Citation | von Geldern, TW; Hoffman, DJ; Kester, JA; Nellans, HN; Dayton, BD; Calzadilla, SV; Marsh, KC; Hernandez, L; Chiou, W; Dixon, DB; Wu-Wong, JR; Opgenorth, TJ Azole endothelin antagonists. 3. Using delta log P as a tool to improve absorption. J Med Chem39:982-91 (1996) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Endothelin-1 receptor |
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Name: | Endothelin-1 receptor |
Synonyms: | EDNRA | EDNRA_HUMAN | ET-A | ETA | ETA-R | ETRA | Endothelin receptor type A | Endothelin receptor, ET-A/ET-B | hET-AR |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 48736.88 |
Organism: | Homo sapiens (Human) |
Description: | P25101 |
Residue: | 427 |
Sequence: | METLCLRASFWLALVGCVISDNPERYSTNLSNHVDDFTTFRGTELSFLVTTHQPTNLVLP
SNGSMHNYCPQQTKITSAFKYINTVISCTIFIVGMVGNATLLRIIYQNKCMRNGPNALIA
SLALGDLIYVVIDLPINVFKLLAGRWPFDHNDFGVFLCKLFPFLQKSSVGITVLNLCALS
VDRYRAVASWSRVQGIGIPLVTAIEIVSIWILSFILAIPEAIGFVMVPFEYRGEQHKTCM
LNATSKFMEFYQDVKDWWLFGFYFCMPLVCTAIFYTLMTCEMLNRRNGSLRIALSEHLKQ
RREVAKTVFCLVVIFALCWFPLHLSRILKKTVYNEMDKNRCELLSFLLLMDYIGINLATM
NSCINPIALYFVSKKFKNCFQSCLCCCCYQSKSLMTSVPMNGTSIQWKNHDQNNHNTDRS
SHKDSMN
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BDBM50050063 |
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n/a |
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Name | BDBM50050063 |
Synonyms: | 2-[(R)-1-[(S)-2-(Cyclohexyl-methyl-carbamoyloxy)-4-methyl-pentanoylamino]-2-(1-methyl-1H-indol-3-yl)-ethyl]-5-methyl-oxazole-4-carboxylic acid | CHEMBL175698 |
Type | Small organic molecule |
Emp. Form. | C30H40N4O6 |
Mol. Mass. | 552.6618 |
SMILES | CC(C)C[C@H](OC(=O)N(C)C1CCCCC1)C(=O)N[C@H](Cc1cn(C)c2ccccc12)c1nc(C(O)=O)c(C)o1 |
Structure |
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