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TargetEndothelin-1 receptor
LigandBDBM50050063
Substrate/Competitorn/a
Meas. Tech.ChEMBL_65491 (CHEMBL682366)
IC50 4.6±n/a nM
Citation von Geldern, TWHoffman, DJKester, JANellans, HNDayton, BDCalzadilla, SVMarsh, KCHernandez, LChiou, WDixon, DBWu-Wong, JROpgenorth, TJ Azole endothelin antagonists. 3. Using delta log P as a tool to improve absorption. J Med Chem39:982-91 (1996) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Endothelin-1 receptor
Name:Endothelin-1 receptor
Synonyms:EDNRA | EDNRA_HUMAN | ET-A | ETA | ETA-R | ETRA | Endothelin receptor type A | Endothelin receptor, ET-A/ET-B | hET-AR
Type:Enzyme Catalytic Domain
Mol. Mass.:48736.88
Organism:Homo sapiens (Human)
Description:P25101
Residue:427
Sequence:
METLCLRASFWLALVGCVISDNPERYSTNLSNHVDDFTTFRGTELSFLVTTHQPTNLVLP
SNGSMHNYCPQQTKITSAFKYINTVISCTIFIVGMVGNATLLRIIYQNKCMRNGPNALIA
SLALGDLIYVVIDLPINVFKLLAGRWPFDHNDFGVFLCKLFPFLQKSSVGITVLNLCALS
VDRYRAVASWSRVQGIGIPLVTAIEIVSIWILSFILAIPEAIGFVMVPFEYRGEQHKTCM
LNATSKFMEFYQDVKDWWLFGFYFCMPLVCTAIFYTLMTCEMLNRRNGSLRIALSEHLKQ
RREVAKTVFCLVVIFALCWFPLHLSRILKKTVYNEMDKNRCELLSFLLLMDYIGINLATM
NSCINPIALYFVSKKFKNCFQSCLCCCCYQSKSLMTSVPMNGTSIQWKNHDQNNHNTDRS
SHKDSMN
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  Blast E-value cutoff:
BDBM50050063
n/a
NameBDBM50050063
Synonyms:2-[(R)-1-[(S)-2-(Cyclohexyl-methyl-carbamoyloxy)-4-methyl-pentanoylamino]-2-(1-methyl-1H-indol-3-yl)-ethyl]-5-methyl-oxazole-4-carboxylic acid | CHEMBL175698
TypeSmall organic molecule
Emp. Form.C30H40N4O6
Mol. Mass.552.6618
SMILESCC(C)C[C@H](OC(=O)N(C)C1CCCCC1)C(=O)N[C@H](Cc1cn(C)c2ccccc12)c1nc(C(O)=O)c(C)o1
Structure
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