| Reaction Details |
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 | Report a problem with these data |
| Target | D(4) dopamine receptor |
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| Ligand | BDBM50050465 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_60678 (CHEMBL674049) |
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| Ki | 0.51±n/a nM |
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| Citation |  Kulagowski, JJ; Broughton, HB; Curtis, NR; Mawer, IM; Ridgill, MP; Baker, R; Emms, F; Freedman, SB; Marwood, R; Patel, S; Patel, S; Ragan, CI; Leeson, PD 3-((4-(4-Chlorophenyl)piperazin-1-yl)-methyl)-1H-pyrrolo-2,3-b-pyridine: an antagonist with high affinity and selectivity for the human dopamine D4 receptor. J Med Chem39:1941-2 (1996) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| D(4) dopamine receptor |
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| Name: | D(4) dopamine receptor |
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| Synonyms: | D(2C) dopamine receptor | DOPAMINE D4 | DOPAMINE D4.2 | DOPAMINE D4.4 | DRD4 | DRD4_HUMAN | Dopamine D4 receptor |
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| Type: | Enzyme |
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| Mol. Mass.: | 48373.19 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P21917 |
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| Residue: | 419 |
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| Sequence: | MGNRSTADADGLLAGRGPAAGASAGASAGLAGQGAAALVGGVLLIGAVLAGNSLVCVSVA
TERALQTPTNSFIVSLAAADLLLALLVLPLFVYSEVQGGAWLLSPRLCDALMAMDVMLCT
ASIFNLCAISVDRFVAVAVPLRYNRQGGSRRQLLLIGATWLLSAAVAAPVLCGLNDVRGR
DPAVCRLEDRDYVVYSSVCSFFLPCPLMLLLYWATFRGLQRWEVARRAKLHGRAPRRPSG
PGPPSPTPPAPRLPQDPCGPDCAPPAPGLPRGPCGPDCAPAAPSLPQDPCGPDCAPPAPG
LPPDPCGSNCAPPDAVRAAALPPQTPPQTRRRRRAKITGRERKAMRVLPVVVGAFLLCWT
PFFVVHITQALCPACSVPPRLVSAVTWLGYVNSALNPVIYTVFNAEFRNVFRKALRACC
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| BDBM50050465 |
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| n/a |
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| Name | BDBM50050465 |
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| Synonyms: | 3-[4-(4-Iodo-phenyl)-piperazin-1-ylmethyl]-1H-pyrrolo[2,3-b]pyridine | CHEMBL60518 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H19IN4 |
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| Mol. Mass. | 418.2747 |
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| SMILES | Ic1ccc(cc1)N1CCN(Cc2c[nH]c3ncccc23)CC1 |
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| Structure | 
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