| Reaction Details |
|---|
 | Report a problem with these data |
| Target | EDNRB |
|---|
| Ligand | BDBM50050807 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_63857 |
|---|
| Ki | 20±n/a nM |
|---|
| Citation |  Riechers H; Albrecht HP; Amberg W; Baumann E; Bernard H; Böhm HJ; Klinge D; Kling A; Müller S; Raschack M; Unger L; Walker N; Wernet W Discovery and optimization of a novel class of orally active nonpeptidic endothelin-A receptor antagonists. J Med Chem 39:2123-8 (1996) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| EDNRB |
|---|
| Name: | Endothelin receptor, ET-A/ET-B |
|---|
| Synonyms: | ENDOTHELIN B | ET-B | Endothelin receptor ET-B | Endothelin receptor non-selective type | Endothelin receptor, ET-A/ET-B |
|---|
| Type: | Enzyme Catalytic Domain |
|---|
| Mol. Mass.: | 49664.00 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ENDOTHELIN B EDNRB HUMAN::P24530 |
|---|
| Residue: | 442 |
|---|
| Sequence: | MQPPPSLCGRALVALVLACGLSRIWGEERGFPPDRATPLLQTAEIMTPPTKTLWPKGSNA
SLARSLAPAEVPKGDRTAGSPPRTISPPPCQGPIEIKETFKYINTVVSCLVFVLGIIGNS
TLLRIIYKNKCMRNGPNILIASLALGDLLHIVIDIPINVYKLLAEDWPFGAEMCKLVPFI
QKASVGITVLSLCALSIDRYRAVASWSRIKGIGVPKWTAVEIVLIWVVSVVLAVPEAIGF
DIITMDYKGSYLRICLLHPVQKTAFMQFYKTAKDWWLFSFYFCLPLAITAFFYTLMTCEM
LRKKSGMQIALNDHLKQRREVAKTVFCLVLVFALCWLPLHLSRILKLTLYNQNDPNRCEL
LSFLLVLDYIGINMASLNSCINPIALYLVSKRFKNCFKSCLCCWCQSFEEKQSLEEKQSC
LKFKANDHGYDNFRSSNKYSSS
|
|
|
|---|
| BDBM50050807 |
|---|
| n/a |
|---|
| Name | BDBM50050807 |
|---|
| Synonyms: | 3-Methoxy-2-(4-methoxy-6-methyl-pyrimidin-2-yloxy)-3,3-diphenyl-propionic acid | CHEMBL303631 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C22H22N2O5 |
|---|
| Mol. Mass. | 394.4205 |
|---|
| SMILES | COc1cc(C)nc(OC(C(O)=O)C(OC)(c2ccccc2)c2ccccc2)n1 |
|---|
| Structure | 
|
|---|
Search and Browse
