Reaction Details |
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Target | Endothelin receptor type B |
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Ligand | BDBM50050798 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_63517 (CHEMBL677267) |
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Ki | 4700±n/a nM |
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Citation | Riechers, H; Albrecht, HP; Amberg, W; Baumann, E; Bernard, H; Böhm, HJ; Klinge, D; Kling, A; Müller, S; Raschack, M; Unger, L; Walker, N; Wernet, W Discovery and optimization of a novel class of orally active nonpeptidic endothelin-A receptor antagonists. J Med Chem39:2123-8 (1996) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Endothelin receptor type B |
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Name: | Endothelin receptor type B |
Synonyms: | EDNRB | EDNRB_HUMAN | ENDOTHELIN B | ET-B | ETRB | Endothelin receptor ET-B | Endothelin receptor non-selective type | Endothelin receptor, ET-A/ET-B |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 49664.00 |
Organism: | Homo sapiens (Human) |
Description: | ENDOTHELIN B EDNRB HUMAN::P24530 |
Residue: | 442 |
Sequence: | MQPPPSLCGRALVALVLACGLSRIWGEERGFPPDRATPLLQTAEIMTPPTKTLWPKGSNA
SLARSLAPAEVPKGDRTAGSPPRTISPPPCQGPIEIKETFKYINTVVSCLVFVLGIIGNS
TLLRIIYKNKCMRNGPNILIASLALGDLLHIVIDIPINVYKLLAEDWPFGAEMCKLVPFI
QKASVGITVLSLCALSIDRYRAVASWSRIKGIGVPKWTAVEIVLIWVVSVVLAVPEAIGF
DIITMDYKGSYLRICLLHPVQKTAFMQFYKTAKDWWLFSFYFCLPLAITAFFYTLMTCEM
LRKKSGMQIALNDHLKQRREVAKTVFCLVLVFALCWLPLHLSRILKLTLYNQNDPNRCEL
LSFLLVLDYIGINMASLNSCINPIALYLVSKRFKNCFKSCLCCWCQSFEEKQSLEEKQSC
LKFKANDHGYDNFRSSNKYSSS
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BDBM50050798 |
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n/a |
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Name | BDBM50050798 |
Synonyms: | 2-(4,6-Dimethoxy-pyrimidin-2-yloxy)-3-(4-methylsulfanyl-phenoxy)-3-phenyl-butyric acid methyl ester | CHEMBL67957 |
Type | Small organic molecule |
Emp. Form. | C24H26N2O6S |
Mol. Mass. | 470.538 |
SMILES | COC(=O)C(Oc1nc(OC)cc(OC)n1)C(C)(Oc1ccc(SC)cc1)c1ccccc1 |
Structure |
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