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TargetRibonucleoside-diphosphate reductase subunit M2
LigandBDBM50051770
Substrate/Competitorn/a
Meas. Tech.ChEMBL_195255
IC50 11000±n/a nM
Citation Liu MCLin TSCory JGCory AHSartorelli AC Synthesis and biological activity of 3- and 5-amino derivatives of pyridine-2-carboxaldehyde thiosemicarbazone. J Med Chem 39:2586-93 (1996) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Ribonucleoside-diphosphate reductase subunit M2
Name:Ribonucleoside-diphosphate reductase subunit M2
Synonyms:RR2 | RRM2 | Ribonucleoside-diphosphate reductase M2 chain | Ribonucleotide reductase small chain | Ribonucleotide reductase small subunit
Type:PROTEIN
Mol. Mass.:44868.59
Organism:Homo sapiens (Human)
Description:ChEMBL_195255
Residue:389
Sequence:
MLSLRVPLAPITDPQQLQLSPLKGLSLVDKENTPPALSGTRVLASKTARRIFQEPTEPKT
KAAAPGVEDEPLLRENPRRFVIFPIEYHDIWQMYKKAEASFWTAEEVDLSKDIQHWESLK
PEERYFISHVLAFFAASDGIVNENLVERFSQEVQITEARCFYGFQIAMENIHSEMYSLLI
DTYIKDPKEREFLFNAIETMPCVKKKADWALRWIGDKEATYGERVVAFAAVEGIFFSGSF
ASIFWLKKRGLMPGLTFSNELISRDEGLHCDFACLMFKHLVHKPSEERVREIIINAVRIE
QEFLTEALPVKLIGMNCTLMKQYIEFVADRLMLELGFSKVFRVENPFDFMENISLEGKTN
FFEKRVGEYQRMGVMSSPTENSFTLDADF
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50051770
n/a
NameBDBM50051770
Synonyms:(1Z,N'E)-N'-((5-amino-4-(morpholinomethyl)pyridin-2-yl)methylene)carbamohydrazonothioic acid | CHEMBL85181
TypeSmall organic molecule
Emp. Form.C12H18N6OS
Mol. Mass.294.376
SMILESNC(=S)NN=Cc1cc(CN2CCOCC2)c(N)cn1 |w:4.3|
Structure
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