| Reaction Details |
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 | Report a problem with these data |
| Target | Ribonucleoside-diphosphate reductase subunit M2 |
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| Ligand | BDBM50051774 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_195255 (CHEMBL796773) |
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| IC50 | 1700±n/a nM |
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| Citation |  Liu, MC; Lin, TS; Cory, JG; Cory, AH; Sartorelli, AC Synthesis and biological activity of 3- and 5-amino derivatives of pyridine-2-carboxaldehyde thiosemicarbazone. J Med Chem39:2586-93 (1996) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Ribonucleoside-diphosphate reductase subunit M2 |
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| Name: | Ribonucleoside-diphosphate reductase subunit M2 |
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| Synonyms: | RIR2_HUMAN | RR2 | RRM2 | Ribonucleoside-diphosphate reductase M2 chain | Ribonucleotide reductase small chain | Ribonucleotide reductase small subunit |
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| Type: | PROTEIN |
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| Mol. Mass.: | 44868.59 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_195255 |
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| Residue: | 389 |
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| Sequence: | MLSLRVPLAPITDPQQLQLSPLKGLSLVDKENTPPALSGTRVLASKTARRIFQEPTEPKT
KAAAPGVEDEPLLRENPRRFVIFPIEYHDIWQMYKKAEASFWTAEEVDLSKDIQHWESLK
PEERYFISHVLAFFAASDGIVNENLVERFSQEVQITEARCFYGFQIAMENIHSEMYSLLI
DTYIKDPKEREFLFNAIETMPCVKKKADWALRWIGDKEATYGERVVAFAAVEGIFFSGSF
ASIFWLKKRGLMPGLTFSNELISRDEGLHCDFACLMFKHLVHKPSEERVREIIINAVRIE
QEFLTEALPVKLIGMNCTLMKQYIEFVADRLMLELGFSKVFRVENPFDFMENISLEGKTN
FFEKRVGEYQRMGVMSSPTENSFTLDADF
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| BDBM50051774 |
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| n/a |
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| Name | BDBM50051774 |
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| Synonyms: | (1Z,N'E)-N'-((3-(allylamino)pyridin-2-yl)methylene)carbamohydrazonothioic acid | CHEMBL87996 |
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| Type | Small organic molecule |
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| Emp. Form. | C10H13N5S |
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| Mol. Mass. | 235.309 |
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| SMILES | NC(=S)NN=Cc1ncccc1NCC=C |w:5.5| |
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| Structure | 
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