Reaction Details | |||
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Target | Squalene synthase | ||
Ligand | BDBM50052351 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_202113 (CHEMBL808971) | ||
IC50 | 121±n/a nM | ||
Citation | Brown, GR; Clarke, DS; Foubister, AJ; Freeman, S; Harrison, PJ; Johnson, MC; Mallion, KB; McCormick, J; McTaggart, F; Reid, AC; Smith, GJ; Taylor, MJ Synthesis and activity of a novel series of 3-biarylquinuclidine squalene synthase inhibitors. J Med Chem39:2971-9 (1996) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Squalene synthase | |||
Name: | Squalene synthase | ||
Synonyms: | FDFT_RAT | FPP:FPP farnesyltransferase | Farnesyl-diphosphate farnesyltransferase | Fdft1 | SQS | SS | Squalene synthetase | ||
Type: | PROTEIN | ||
Mol. Mass.: | 48109.41 | ||
Organism: | Rattus norvegicus | ||
Description: | ChEMBL_1336736 | ||
Residue: | 416 | ||
Sequence: |
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BDBM50052351 | |||
n/a | |||
Name | BDBM50052351 | ||
Synonyms: | 3-Biphenyl-4-yl-1-aza-bicyclo[2.2.2]octan-3-ol | 3-biphenyl-4-yl-3-hydroxyquinuclidine | CHEMBL279261 | ||
Type | Small organic molecule | ||
Emp. Form. | C19H21NO | ||
Mol. Mass. | 279.3761 | ||
SMILES | OC1(CN2CCC1CC2)c1ccc(cc1)-c1ccccc1 |(10.58,-8.89,;10.59,-10.42,;10.59,-11.97,;9.25,-12.74,;7.92,-11.97,;7.92,-10.42,;9.25,-9.65,;8.51,-11,;10,-11.41,;11.92,-9.66,;13.25,-10.43,;14.59,-9.66,;14.59,-8.12,;13.25,-7.35,;11.92,-8.12,;15.92,-7.35,;17.25,-8.12,;18.58,-7.36,;18.58,-5.81,;17.24,-5.04,;15.91,-5.82,)| | ||
Structure |