Reaction Details | |||
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Target | Squalene synthase | ||
Ligand | BDBM50052377 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_202113 (CHEMBL808971) | ||
IC50 | 8±n/a nM | ||
Citation | Brown, GR; Clarke, DS; Foubister, AJ; Freeman, S; Harrison, PJ; Johnson, MC; Mallion, KB; McCormick, J; McTaggart, F; Reid, AC; Smith, GJ; Taylor, MJ Synthesis and activity of a novel series of 3-biarylquinuclidine squalene synthase inhibitors. J Med Chem39:2971-9 (1996) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Squalene synthase | |||
Name: | Squalene synthase | ||
Synonyms: | FDFT_RAT | FPP:FPP farnesyltransferase | Farnesyl-diphosphate farnesyltransferase | Fdft1 | SQS | SS | Squalene synthetase | ||
Type: | PROTEIN | ||
Mol. Mass.: | 48109.41 | ||
Organism: | Rattus norvegicus | ||
Description: | ChEMBL_1336736 | ||
Residue: | 416 | ||
Sequence: |
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BDBM50052377 | |||
n/a | |||
Name | BDBM50052377 | ||
Synonyms: | 3-(Biphenyl-4-ylsulfanylmethyl)-1-aza-bicyclo[2.2.2]octan-3-ol | CHEMBL319172 | ||
Type | Small organic molecule | ||
Emp. Form. | C20H23NOS | ||
Mol. Mass. | 325.468 | ||
SMILES | OC1(CSc2ccc(cc2)-c2ccccc2)CN2CCC1CC2 |THB:2:1:21.22:19.18,0:1:21.22:19.18,(12.09,-8,;11.74,-10.14,;13.28,-10.14,;14.12,-11.43,;15.68,-11.32,;16.49,-12.62,;18.05,-12.55,;18.73,-11.15,;17.89,-9.86,;16.35,-9.96,;20.26,-11.07,;21.12,-12.36,;22.66,-12.27,;23.36,-10.87,;22.5,-9.58,;20.96,-9.68,;12.05,-11.64,;10.56,-10.96,;8.88,-11.67,;8.67,-10.17,;10.28,-9.47,;10.28,-7.62,;10.84,-8.9,)| | ||
Structure |