| Reaction Details |
|---|
 | Report a problem with these data |
| Target | 5-lipoxygenase |
|---|
| Ligand | BDBM50052470 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_3988 (CHEMBL619260) |
|---|
| IC50 | 3000±n/a nM |
|---|
| Citation |  Müller, K; Huang, HS; Wiegrebe, W Antipsoriatic anthrones with modulated redox properties. 3. 10-thio-substituted 1,8-dihydroxy-9(10H)-anthracenones as inhibitors of keratinocyte growth, 5-lipoxygenase, and the formation of 12(S)-HETE in mouse epidermis. J Med Chem39:3132-8 (1996) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| 5-lipoxygenase |
|---|
| Name: | 5-lipoxygenase |
|---|
| Synonyms: | Arachidonate 5-lipoxygenase |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 49994.23 |
|---|
| Organism: | Bos taurus |
|---|
| Description: | ChEMBL_157766 |
|---|
| Residue: | 430 |
|---|
| Sequence: | MPSYTVTVATGSQWFAGTDDYIYLSLVGSAGCSEKHLLDKPFYNDFERGAVDSYDVTVDE
ELGDIQLIKIEKRKYWFHDDWYLKYITVKTPCGDYIEFPCYRWISGEGEIVLRDGQAKLA
CDDQIHVLKQHRRKELETRQKQYRWMEWNPGFPLSIDAKCHKDLPRDIQFDSEKGVDFVL
NYSKAMENLFINRFMHMFQSSWSDFADFEKIFVRISNTISERVMNHWQEDRMFGYQFLNG
CNPVMIQRCLKLPDNLPVTTEMVECSLERQLTLEQEIEQGNIFIVDFKLLDGIDANKTDP
CTLQFLAAPICLLYKNLANKIVPIAIQLNQVPGEENPIFLPSDAKYDWLLAKIWVRSSDF
HVHQTITHLLRTHLVSEVFGIAMYRQLPAVHPIFKLLVAHVRFTIAINTKAREQLICEYG
LFDKANATGG
|
|
|
|---|
| BDBM50052470 |
|---|
| n/a |
|---|
| Name | BDBM50052470 |
|---|
| Synonyms: | 1,8-Dihydroxy-10-(4-methoxy-phenylsulfanyl)-10H-anthracen-9-one | CHEMBL104361 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C21H16O4S |
|---|
| Mol. Mass. | 364.414 |
|---|
| SMILES | COc1ccc(SC2c3cccc(O)c3C(=O)c3c(O)cccc23)cc1 |
|---|
| Structure | 
|
|---|
Search and Browse
