| Reaction Details |
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 | Report a problem with these data |
| Target | Retinoic acid receptor alpha |
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| Ligand | BDBM50052590 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_197383 (CHEMBL799702) |
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| EC50 | 14±n/a nM |
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| Citation |  Canan Koch, SS; Dardashti, LJ; Hebert, JJ; White, SK; Croston, GE; Flatten, KS; Heyman, RA; Nadzan, AM Identification of the first retinoid X, receptor homodimer antagonist. J Med Chem39:3229-34 (1996) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Retinoic acid receptor alpha |
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| Name: | Retinoic acid receptor alpha |
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| Synonyms: | NR1B1 | Nuclear receptor subfamily 1 group B member 1 | RAR-alpha | RARA | RARA_HUMAN | Retinoic acid receptor alpha | Retinoic acid receptor alpha/Retinoid X receptor alpha | Retinoid X receptor gamma/retinoic acid receptor alpha | Retinoid receptor |
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| Type: | PROTEIN |
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| Mol. Mass.: | 50778.87 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1466191 |
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| Residue: | 462 |
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| Sequence: | MASNSSSCPTPGGGHLNGYPVPPYAFFFPPMLGGLSPPGALTTLQHQLPVSGYSTPSPAT
IETQSSSSEEIVPSPPSPPPLPRIYKPCFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNM
VYTCHRDKNCIINKVTRNRCQYCRLQKCFEVGMSKESVRNDRNKKKKEVPKPECSESYTL
TPEVGELIEKVRKAHQETFPALCQLGKYTTNNSSEQRVSLDIDLWDKFSELSTKCIIKTV
EFAKQLPGFTTLTIADQITLLKAACLDILILRICTRYTPEQDTMTFSDGLTLNRTQMHNA
GFGPLTDLVFAFANQLLPLEMDDAETGLLSAICLICGDRQDLEQPDRVDMLQEPLLEALK
VYVRKRRPSRPHMFPKMLMKITDLRSISAKGAERVITLKMEIPGSMPPLIQEMLENSEGL
DTLSGQPGGGGRDGGGLAPPPGSCSPSLSPSSNRSSPATHSP
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| BDBM50052590 |
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| n/a |
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| Name | BDBM50052590 |
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| Synonyms: | (2E,4E,6Z)-7-(3-Ethoxy-5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-3-methyl-octa-2,4,6-trienoic acid | CHEMBL109847 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H34O3 |
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| Mol. Mass. | 382.5357 |
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| SMILES | CCOc1cc2c(cc1\C(C)=C/C=C/C(/C)=C/C(O)=O)C(C)(C)CCC2(C)C |
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| Structure | 
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