| Reaction Details |
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 | Report a problem with these data |
| Target | Low-density lipoprotein receptor |
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| Ligand | BDBM50052678 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_99545 (CHEMBL707778) |
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| EC50 | 1300±n/a nM |
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| Citation |  Ashton, MJ; Brown, TJ; Fenton, G; Halley, F; Harper, MF; Lockey, PM; Porter, B; Roach, AG; Stuttle, KA; Vicker, N; Walsh, RJ New low-density lipoprotein receptor upregulators acting via a novel mechanism. J Med Chem39:3343-56 (1996) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Low-density lipoprotein receptor |
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| Name: | Low-density lipoprotein receptor |
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| Synonyms: | LDL receptor | LDLR | LDLR_HUMAN | Low-density lipoprotein receptor |
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| Type: | PROTEIN |
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| Mol. Mass.: | 95343.42 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_99545 |
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| Residue: | 860 |
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| Sequence: | MGPWGWKLRWTVALLLAAAGTAVGDRCERNEFQCQDGKCISYKWVCDGSAECQDGSDESQ
ETCLSVTCKSGDFSCGGRVNRCIPQFWRCDGQVDCDNGSDEQGCPPKTCSQDEFRCHDGK
CISRQFVCDSDRDCLDGSDEASCPVLTCGPASFQCNSSTCIPQLWACDNDPDCEDGSDEW
PQRCRGLYVFQGDSSPCSAFEFHCLSGECIHSSWRCDGGPDCKDKSDEENCAVATCRPDE
FQCSDGNCIHGSRQCDREYDCKDMSDEVGCVNVTLCEGPNKFKCHSGECITLDKVCNMAR
DCRDWSDEPIKECGTNECLDNNGGCSHVCNDLKIGYECLCPDGFQLVAQRRCEDIDECQD
PDTCSQLCVNLEGGYKCQCEEGFQLDPHTKACKAVGSIAYLFFTNRHEVRKMTLDRSEYT
SLIPNLRNVVALDTEVASNRIYWSDLSQRMICSTQLDRAHGVSSYDTVISRDIQAPDGLA
VDWIHSNIYWTDSVLGTVSVADTKGVKRKTLFRENGSKPRAIVVDPVHGFMYWTDWGTPA
KIKKGGLNGVDIYSLVTENIQWPNGITLDLLSGRLYWVDSKLHSISSIDVNGGNRKTILE
DEKRLAHPFSLAVFEDKVFWTDIINEAIFSANRLTGSDVNLLAENLLSPEDMVLFHNLTQ
PRGVNWCERTTLSNGGCQYLCLPAPQINPHSPKFTCACPDGMLLARDMRSCLTEAEAAVA
TQETSTVRLKVSSTAVRTQHTTTRPVPDTSRLPGATPGLTTVEIVTMSHQALGDVAGRGN
EKKPSSVRALSIVLPIVLLVFLCLGVFLLWKNWRLKNINSINFDNPVYQKTTEDEVHICH
NQDGYSYPSRQMVSLEDDVA
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| BDBM50052678 |
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| n/a |
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| Name | BDBM50052678 |
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| Synonyms: | 3-Cyclohexyl-N-[4-methyl-3-(5-methyl-1H-benzoimidazol-2-yl)-phenyl]-propionamide | CHEMBL114810 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H29N3O |
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| Mol. Mass. | 375.5066 |
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| SMILES | Cc1ccc2nc([nH]c2c1)-c1cc(NC(=O)CCC2CCCCC2)ccc1C |
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| Structure | 
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