| Reaction Details |
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 | Report a problem with these data |
| Target | Low-density lipoprotein receptor |
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| Ligand | BDBM50052681 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_99545 (CHEMBL707778) |
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| EC50 | 700±n/a nM |
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| Citation |  Ashton, MJ; Brown, TJ; Fenton, G; Halley, F; Harper, MF; Lockey, PM; Porter, B; Roach, AG; Stuttle, KA; Vicker, N; Walsh, RJ New low-density lipoprotein receptor upregulators acting via a novel mechanism. J Med Chem39:3343-56 (1996) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Low-density lipoprotein receptor |
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| Name: | Low-density lipoprotein receptor |
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| Synonyms: | LDL receptor | LDLR | LDLR_HUMAN | Low-density lipoprotein receptor |
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| Type: | PROTEIN |
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| Mol. Mass.: | 95343.42 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_99545 |
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| Residue: | 860 |
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| Sequence: | MGPWGWKLRWTVALLLAAAGTAVGDRCERNEFQCQDGKCISYKWVCDGSAECQDGSDESQ
ETCLSVTCKSGDFSCGGRVNRCIPQFWRCDGQVDCDNGSDEQGCPPKTCSQDEFRCHDGK
CISRQFVCDSDRDCLDGSDEASCPVLTCGPASFQCNSSTCIPQLWACDNDPDCEDGSDEW
PQRCRGLYVFQGDSSPCSAFEFHCLSGECIHSSWRCDGGPDCKDKSDEENCAVATCRPDE
FQCSDGNCIHGSRQCDREYDCKDMSDEVGCVNVTLCEGPNKFKCHSGECITLDKVCNMAR
DCRDWSDEPIKECGTNECLDNNGGCSHVCNDLKIGYECLCPDGFQLVAQRRCEDIDECQD
PDTCSQLCVNLEGGYKCQCEEGFQLDPHTKACKAVGSIAYLFFTNRHEVRKMTLDRSEYT
SLIPNLRNVVALDTEVASNRIYWSDLSQRMICSTQLDRAHGVSSYDTVISRDIQAPDGLA
VDWIHSNIYWTDSVLGTVSVADTKGVKRKTLFRENGSKPRAIVVDPVHGFMYWTDWGTPA
KIKKGGLNGVDIYSLVTENIQWPNGITLDLLSGRLYWVDSKLHSISSIDVNGGNRKTILE
DEKRLAHPFSLAVFEDKVFWTDIINEAIFSANRLTGSDVNLLAENLLSPEDMVLFHNLTQ
PRGVNWCERTTLSNGGCQYLCLPAPQINPHSPKFTCACPDGMLLARDMRSCLTEAEAAVA
TQETSTVRLKVSSTAVRTQHTTTRPVPDTSRLPGATPGLTTVEIVTMSHQALGDVAGRGN
EKKPSSVRALSIVLPIVLLVFLCLGVFLLWKNWRLKNINSINFDNPVYQKTTEDEVHICH
NQDGYSYPSRQMVSLEDDVA
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| BDBM50052681 |
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| n/a |
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| Name | BDBM50052681 |
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| Synonyms: | CHEMBL114890 | N-[3-((Z)-2-Benzo[1,3]dioxol-5-yl-2-cyano-vinyl)-4-methyl-phenyl]-3-cyclohexyl-propionamide |
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| Type | Small organic molecule |
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| Emp. Form. | C26H28N2O3 |
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| Mol. Mass. | 416.5121 |
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| SMILES | Cc1ccc(NC(=O)CCC2CCCCC2)cc1\C=C(/C#N)c1ccc2OCOc2c1 |
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| Structure | 
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