| Reaction Details |
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 | Report a problem with these data |
| Target | Retinoic acid receptor alpha |
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| Ligand | BDBM50035477 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_195184 (CHEMBL801817) |
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| IC50 | 8±n/a nM |
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| Citation |  Muccio, DD; Brouillette, WJ; Alam, M; Vaezi, MF; Sani, BP; Venepally, P; Reddy, L; Li, E; Norris, AW; Simpson-Herren, L; Hill, DL Conformationally defined 6-s-trans-retinoic acid analogs. 3. Structure-activity relationships for nuclear receptor binding, transcriptional activity, and cancer chemopreventive activity. J Med Chem39:3625-35 (1996) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Retinoic acid receptor alpha |
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| Name: | Retinoic acid receptor alpha |
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| Synonyms: | Nr1b1 | RARA_MOUSE | Rara |
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| Type: | PROTEIN |
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| Mol. Mass.: | 50742.79 |
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| Organism: | Mus musculus |
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| Description: | ChEMBL_195182 |
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| Residue: | 462 |
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| Sequence: | MASNSSSCPTPGGGHLNGYPVPPYAFFFPPMLGGLSPPGALTSLQHQLPVSGYSTPSPAT
IETQSSSSEEIVPSPPSPPPLPRIYKPCFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNM
VYTCHRDKNCIINKVTRNRCQYCRLQKCFDVGMSKESVRNDRNKKKKEAPKPECSESYTL
TPEVGELIEKVRKAHQETFPALCQLGKYTTNNSSEQRVSLDIDLWDKFSELSTKCIIKTV
EFAKQLPGFTTLTIADQITLLKAACLDILILRICTRYTPEQDTMTFSDGLTLNRTQMHNA
GFGPLTDLVFAFANQLLPLEMDDAETGLLSAICLICGDRQDLEQPDKVDMLQEPLLEALK
VYVRKRRPSRPHMFPKMLMKITDLRSISAKGAERVITLKMEIPGSMPPLIQEMLENSEGL
DTLSGQSGGGTRDGGGLAPPPGSCSPSLSPSSHRSSPATQSP
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| BDBM50035477 |
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| n/a |
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| Name | BDBM50035477 |
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| Synonyms: | (2E,4E,6E)-8-[2-Isopropyl-3-methyl-cyclohex-2-en-(E)-ylidene]-3,7-dimethyl-octa-2,4,6-trienoic acid | CHEMBL333032 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H28O2 |
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| Mol. Mass. | 300.4351 |
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| SMILES | CC(C)C1=C(C)CCC\C1=C/C(/C)=C/C=C/C(/C)=C/C(O)=O |c:3| |
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| Structure | 
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