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TargetCathepsin (B and K)
LigandBDBM50053859
Substrate/Competitorn/a
Meas. Tech.ChEMBL_47427
Ki 0.28±n/a nM
Citation Li ZOrtega-Vilain ACPatil GSChu DLForeman JEEveleth DDPowers JC Novel peptidyl alpha-keto amide inhibitors of calpains and other cysteine proteases. J Med Chem 39:4089-98 (1996) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Cathepsin (B and K)
Name:Cathepsin (B and K)
Synonyms:APP secretase | APPS | Cathepsin B | Cathepsin B heavy chain | Cathepsin B light chain | Cathepsin B1
Type:Enzyme
Mol. Mass.:37819.69
Organism:Homo sapiens (Human)
Description:gi_63102437
Residue:339
Sequence:
MWQLWASLCCLLVLANARSRPSFHPLSDELVNYVNKRNTTWQAGHNFYNVDMSYLKRLCG
TFLGGPKPPQRVMFTEDLKLPASFDAREQWPQCPTIKEIRDQGSCGSCWAFGAVEAISDR
ICIHTNAHVSVEVSAEDLLTCCGSMCGDGCNGGYPAEAWNFWTRKGLVSGGLYESHVGCR
PYSIPPCEHHVNGSRPPCTGEGDTPKCSKICEPGYSPTYKQDKHYGYNSYSVSNSEKDIM
AEIYKNGPVEGAFSVYSDFLLYKSGVYQHVTGEMMGGHAIRILGWGVENGTPYWLVANSW
NTDWGDNGFFKILRGQDHCGIESEVVAGIPRTDQYWEKI
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50053859
n/a
NameBDBM50053859
Synonyms:CHEMBL133106 | {1-[1-(5-Hydroxy-pentylaminooxalyl)-propylcarbamoyl]-3-methyl-butyl}-carbamic acid benzyl ester
TypeSmall organic molecule
Emp. Form.C24H37N3O6
Mol. Mass.463.5671
SMILESCCC(NC(=O)C(CC(C)C)NC(=O)OCc1ccccc1)C(=O)C(=O)NCCCCCO
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: