| Reaction Details |
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 | Report a problem with these data |
| Target | Cathepsin B |
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| Ligand | BDBM50053791 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_47385 (CHEMBL659000) |
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| Ki | 230±n/a nM |
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| Citation |  Li, Z; Ortega-Vilain, AC; Patil, GS; Chu, DL; Foreman, JE; Eveleth, DD; Powers, JC Novel peptidyl alpha-keto amide inhibitors of calpains and other cysteine proteases. J Med Chem39:4089-98 (1996) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cathepsin B |
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| Name: | Cathepsin B |
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| Synonyms: | BCSB | CATB_BOVIN | CTSB | Cathepsin B precursor | Cathepsin B1 |
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| Type: | Enzyme |
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| Mol. Mass.: | 36657.87 |
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| Organism: | Bos taurus (bovine) |
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| Description: | Bovine spleen CB was purchased from Sigma Co. (USA). |
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| Residue: | 335 |
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| Sequence: | MWRLLATLSCLLVLTSARSSLYFPPLSDELVNFVNKQNTTWKAGHNFYNVDLSYVKKLCG
AILGGPKLPQRDAFAADVVLPESFDAREQWPNCPTIKEIRDQGSCGSCWAFGAVEAISDR
ICIHSNGRVNVEVSAEDMLTCCGGECGDGCNGGFPSGAWNFWTKKGLVSGGLYNSHVGCR
PYSIPPCEHHVNGSRPPCTGEGDTPKCSKTCEPGYSPSYKEDKHFGCSSYSVANNEKEIM
AEIYKNGPVEGAFSVYSDFLLYKSGVYQHVSGEIMGGHAIRILGWGVENGTPYWLVGNSW
NTDWGDNGFFKILRGQDHCGIESEIVAGMPCTHQY
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| BDBM50053791 |
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| n/a |
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| Name | BDBM50053791 |
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| Synonyms: | CHEMBL132566 | [1-(1-Benzyl-2-oxo-2-{2-[5-((3aR,6S,6aS)-2-oxo-hexahydro-thieno[3,4-d]imidazol-6-yl)-pentanoylamino]-ethylcarbamoyl}-ethylcarbamoyl)-3-methyl-butyl]-carbamic acid benzyl ester |
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| Type | Small organic molecule |
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| Emp. Form. | C36H48N6O7S |
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| Mol. Mass. | 708.867 |
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| SMILES | CC(C)CC(NC(=O)OCc1ccccc1)C(=O)NC(Cc1ccccc1)C(=O)C(=O)NCCNC(=O)CCCC[C@@H]1SC[C@@H]2NC(=O)N[C@H]12 |
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| Structure | 
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