| Reaction Details |
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 | Report a problem with these data |
| Target | Inosine-5'-monophosphate dehydrogenase 2 |
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| Ligand | BDBM19264 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_89807 (CHEMBL698525) |
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| pH | 8±n/a |
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| IC50 | 24.8±n/a nM |
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| Comments | extracted |
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| Citation |  Nelson, PH; Carr, SF; Devens, BH; Eugui, EM; Franco, F; Gonzalez, C; Hawley, RC; Loughhead, DG; Milan, DJ; Papp, E; Patterson, JW; Rouhafza, S; Sjogren, EB; Smith, DB; Stephenson, RA; Talamas, FX; Waltos, AM; Weikert, RJ; Wu, JC Structure-activity relationships for inhibition of inosine monophosphate dehydrogenase by nuclear variants of mycophenolic acid. J Med Chem39:4181-96 (1996) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Inosine-5'-monophosphate dehydrogenase 2 |
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| Name: | Inosine-5'-monophosphate dehydrogenase 2 |
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| Synonyms: | IMDH2_HUMAN | IMP dehydrogenase 2 | IMPD 2 | IMPD2 | IMPDH-II | IMPDH2 | Inosine 5'-monophosphate dehydrogenase II (IMPDH II) | Inosine Monophosphate Dehydrogenase Type 2 (IMPDH2) | Inosine-5 -monophosphate dehydrogenase 2 | Inosine-5'-monophosphate dehydrogenase (IMPDH) |
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| Type: | Enzyme |
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| Mol. Mass.: | 55806.87 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Recombinant IMPDH2 expressed in E. coli. |
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| Residue: | 514 |
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| Sequence: | MADYLISGGTSYVPDDGLTAQQLFNCGDGLTYNDFLILPGYIDFTADQVDLTSALTKKIT
LKTPLVSSPMDTVTEAGMAIAMALTGGIGFIHHNCTPEFQANEVRKVKKYEQGFITDPVV
LSPKDRVRDVFEAKARHGFCGIPITDTGRMGSRLVGIISSRDIDFLKEEEHDCFLEEIMT
KREDLVVAPAGITLKEANEILQRSKKGKLPIVNEDDELVAIIARTDLKKNRDYPLASKDA
KKQLLCGAAIGTHEDDKYRLDLLAQAGVDVVVLDSSQGNSIFQINMIKYIKDKYPNLQVI
GGNVVTAAQAKNLIDAGVDALRVGMGSGSICITQEVLACGRPQATAVYKVSEYARRFGVP
VIADGGIQNVGHIAKALALGASTVMMGSLLAATTEAPGEYFFSDGIRLKKYRGMGSLDAM
DKHLSSQNRYFSEADKIKVAQGVSGAVQDKGSIHKFVPYLIAGIQHSCQDIGAKSLTQVR
AMMYSGELKFEKRTSSAQVEGGVHSLHSYEKRLF
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| BDBM19264 |
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| n/a |
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| Name | BDBM19264 |
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| Synonyms: | (4E)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4-methylhex-4-enoic acid | (E)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1H-2-benzofuran-5-yl)-4-methylhex-4-enoic acid | CHEMBL866 | MPA (1) | Mycophenolic Acid (MPA) | Myfortic |
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| Type | Small organic molecule |
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| Emp. Form. | C17H20O6 |
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| Mol. Mass. | 320.3371 |
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| SMILES | COc1c(C)c2COC(=O)c2c(O)c1C\C=C(/C)CCC(O)=O |
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| Structure | 
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