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TargetPhospholipase A2, membrane associated
LigandBDBM50055384
Substrate/Competitorn/a
Meas. Tech.ChEMBL_156189 (CHEMBL761440)
IC50 9±n/a nM
Citation Draheim, SEBach, NJDillard, RDBerry, DRCarlson, DGChirgadze, NYClawson, DKHartley, LWJohnson, LMJones, NDMcKinney, ERMihelich, EDOlkowski, JLSchevitz, RWSmith, ACSnyder, DWSommers, CDWery, JP Indole inhibitors of human nonpancreatic secretory phospholipase A2. 3. Indole-3-glyoxamides. J Med Chem39:5159-75 (1997) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Phospholipase A2, membrane associated
Name:Phospholipase A2, membrane associated
Synonyms:GIIC sPLA2 | Group IIA phospholipase A2 | NPS-PLA2 | Non-Pancreatic Secretory Phospholipase A2 | Non-pancreatic secretory phospholipase A2 (hnps-PLA2) | PA2GA_HUMAN | PLA2B | PLA2G2A | PLA2L | Phosphatidylcholine 2-acylhydrolase | Phospholipase A2 group IIA | RASF-A
Type:Hydrolase
Mol. Mass.:16101.20
Organism:Homo sapiens (Human)
Description:The human nps PLA2 was cloned, and expressed in E. coli. There was a refolding process in the purification.
Residue:144
Sequence:
MKTLLLLAVIMIFGLLQAHGNLVNFHRMIKLTTGKEAALSYGFYGCHCGVGGRGSPKDAT
DRCCVTHDCCYKRLEKRGCGTKFLSYKFSNSGSRITCAKQDSCRSQLCECDKAAATCFAR
NKTTYNKKYQYYSNKHCRGSTPRC
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BDBM50055384
n/a
NameBDBM50055384
Synonyms:(3-Aminooxalyl-1-biphenyl-3-ylmethyl-2-methyl-1H-indol-4-yloxy)-acetic acid | CHEMBL355944
TypeSmall organic molecule
Emp. Form.C26H22N2O5
Mol. Mass.442.4633
SMILESCc1c(C(=O)C(N)=O)c2c(OCC(O)=O)cccc2n1Cc1cccc(c1)-c1ccccc1
Structure
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