Reaction Details |
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Target | Gag-Pol polyprotein [489-587] |
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Ligand | BDBM50055589 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_157575 (CHEMBL763326) |
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Ki | 0.058±n/a nM |
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Citation | Jadhav, PK; Ala, P; Woerner, FJ; Chang, CH; Garber, SS; Anton, ED; Bacheler, LT Cyclic urea amides: HIV-1 protease inhibitors with low nanomolar potency against both wild type and protease inhibitor resistant mutants of HIV. J Med Chem40:181-91 (1997) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Gag-Pol polyprotein [489-587] |
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Name: | Gag-Pol polyprotein [489-587] |
Synonyms: | Human immunodeficiency virus type 1 protease | POL_HV1H2 | Pol polyprotein | gag-pol |
Type: | Enzyme Subunit |
Mol. Mass.: | 10781.16 |
Organism: | Human immunodeficiency virus type 1 |
Description: | P04585[489-587] |
Residue: | 99 |
Sequence: | PQVTLWQRPLVTIKIGGQLKEALLDTGADDTVLEEMSLPGRWKPKMIGGIGGFIKVRQYD
QILIEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF
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BDBM50055589 |
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n/a |
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Name | BDBM50055589 |
Synonyms: | 3-((4R,5S,6S,7R)-4,7-Dibenzyl-3-cyclopropylmethyl-5,6-dihydroxy-2-oxo-[1,3]diazepan-1-ylmethyl)-N-thiazol-2-yl-benzamide | CHEMBL301213 | [4R--(1ALPHA,5ALPHA,7BETA)]-3-[(CYCLOPROPHYLMETHYL)HEXAHYDRO-5,6-DIHYDROXY-2-OXO-4,7-BIS(PHENYLMETHYL)-1H-1,3-DIAZEPIN]METHYL-2-THIAZOLYLBENZAMIDE |
Type | Small organic molecule |
Emp. Form. | C34H36N4O4S |
Mol. Mass. | 596.739 |
SMILES | O[C@@H]1[C@@H](O)[C@@H](Cc2ccccc2)N(Cc2cccc(c2)C(=O)Nc2nccs2)C(=O)N(CC2CC2)[C@@H]1Cc1ccccc1 |
Structure |
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