| Reaction Details |
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 | Report a problem with these data |
| Target | Protein kinase C eta type |
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| Ligand | BDBM3150 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_161125 (CHEMBL770096) |
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| IC50 | 60±n/a nM |
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| Citation |  Lai, YS; Mendoza, JS; Jagdmann, GE; Menaldino, DS; Biggers, CK; Heerding, JM; Wilson, JW; Hall, SE; Jiang, JB; Janzen, WP; Ballas, LM Synthesis and protein kinase C inhibitory activities of balanol analogs with replacement of the perhydroazepine moiety. J Med Chem40:226-35 (1997) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Protein kinase C eta type |
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| Name: | Protein kinase C eta type |
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| Synonyms: | KPCL_HUMAN | PKC-L | PKCL | PRKCH | PRKCL | Protein Kinase C, eta | Protein kinase C, PKC; classical/novel | nPKC-eta |
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| Type: | Enzyme |
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| Mol. Mass.: | 77844.26 |
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| Organism: | Homo sapiens (Human) |
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| Description: | The recombinant human PKC enzymes were
produced using a baculovirus expression system in SF9 cells |
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| Residue: | 683 |
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| Sequence: | MSSGTMKFNGYLRVRIGEAVGLQPTRWSLRHSLFKKGHQLLDPYLTVSVDQVRVGQTSTK
QKTNKPTYNEEFCANVTDGGHLELAVFHETPLGYDHFVANCTLQFQELLRTTGASDTFEG
WVDLEPEGKVFVVITLTGSFTEATLQRDRIFKHFTRKRQRAMRRRVHQINGHKFMATYLR
QPTYCSHCREFIWGVFGKQGYQCQVCTCVVHKRCHHLIVTACTCQNNINKVDSKIAEQRF
GINIPHKFSIHNYKVPTFCDHCGSLLWGIMRQGLQCKICKMNVHIRCQANVAPNCGVNAV
ELAKTLAGMGLQPGNISPTSKLVSRSTLRRQGKESSKEGNGIGVNSSNRLGIDNFEFIRV
LGKGSFGKVMLARVKETGDLYAVKVLKKDVILQDDDVECTMTEKRILSLARNHPFLTQLF
CCFQTPDRLFFVMEFVNGGDLMFHIQKSRRFDEARARFYAAEIISALMFLHDKGIIYRDL
KLDNVLLDHEGHCKLADFGMCKEGICNGVTTATFCGTPDYIAPEILQEMLYGPAVDWWAM
GVLLYEMLCGHAPFEAENEDDLFEAILNDEVVYPTWLHEDATGILKSFMTKNPTMRLGSL
TQGGEHAILRHPFFKEIDWAQLNHRQIEPPFRPRIKSREDVSNFDPDFIKEEPVLTPIDE
GHLPMINQDEFRNFSYVSPELQP
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| BDBM3150 |
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| n/a |
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| Name | BDBM3150 |
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| Synonyms: | 2-{[2,6-dihydroxy-4-({[(1R,2R)-2-[(4-hydroxybenzene)amido]cycloheptyl]oxy}carbonyl)phenyl]carbonyl}-3-hydroxybenzoic acid | Balanol analog 2 | CHEMBL304549 |
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| Type | Small organic molecule |
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| Emp. Form. | C29H27NO10 |
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| Mol. Mass. | 549.5254 |
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| SMILES | OC(=O)c1cccc(O)c1C(=O)c1c(O)cc(cc1O)C(=O)O[C@@H]1CCCCC[C@H]1NC(=O)c1ccc(O)cc1 |r| |
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| Structure | 
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