| Reaction Details |
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 | Report a problem with these data |
| Target | Protein kinase C gamma type |
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| Ligand | BDBM50055672 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_161269 (CHEMBL767890) |
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| IC50 | 5±n/a nM |
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| Citation |  Lai, YS; Mendoza, JS; Jagdmann, GE; Menaldino, DS; Biggers, CK; Heerding, JM; Wilson, JW; Hall, SE; Jiang, JB; Janzen, WP; Ballas, LM Synthesis and protein kinase C inhibitory activities of balanol analogs with replacement of the perhydroazepine moiety. J Med Chem40:226-35 (1997) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Protein kinase C gamma type |
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| Name: | Protein kinase C gamma type |
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| Synonyms: | KPCG_HUMAN | PKC gamma | PKC-gamma | PKCG | PRKCG | Protein kinase C gamma | Protein kinase C gamma type | Protein kinase C, PKC; classical/novel | Protein kinase C, gamma |
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| Type: | Enzyme |
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| Mol. Mass.: | 78458.05 |
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| Organism: | Homo sapiens (Human) |
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| Description: | The recombinant human PKC enzymes were
produced using a baculovirus expression system in SF9 cells
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| Residue: | 697 |
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| Sequence: | MAGLGPGVGDSEGGPRPLFCRKGALRQKVVHEVKSHKFTARFFKQPTFCSHCTDFIWGIG
KQGLQCQVCSFVVHRRCHEFVTFECPGAGKGPQTDDPRNKHKFRLHSYSSPTFCDHCGSL
LYGLVHQGMKCSCCEMNVHRRCVRSVPSLCGVDHTERRGRLQLEIRAPTADEIHVTVGEA
RNLIPMDPNGLSDPYVKLKLIPDPRNLTKQKTRTVKATLNPVWNETFVFNLKPGDVERRL
SVEVWDWDRTSRNDFMGAMSFGVSELLKAPVDGWYKLLNQEEGEYYNVPVADADNCSLLQ
KFEACNYPLELYERVRMGPSSSPIPSPSPSPTDPKRCFFGASPGRLHISDFSFLMVLGKG
SFGKVMLAERRGSDELYAIKILKKDVIVQDDDVDCTLVEKRVLALGGRGPGGRPHFLTQL
HSTFQTPDRLYFVMEYVTGGDLMYHIQQLGKFKEPHAAFYAAEIAIGLFFLHNQGIIYRD
LKLDNVMLDAEGHIKITDFGMCKENVFPGTTTRTFCGTPDYIAPEIIAYQPYGKSVDWWS
FGVLLYEMLAGQPPFDGEDEEELFQAIMEQTVTYPKSLSREAVAICKGFLTKHPGKRLGS
GPDGEPTIRAHGFFRWIDWERLERLEIPPPFRPRPCGRSGENFDKFFTRAAPALTPPDRL
VLASIDQADFQGFTYVNPDFVHPDARSPTSPVPVPVM
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| BDBM50055672 |
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| n/a |
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| Name | BDBM50055672 |
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| Synonyms: | 4-(2-Carboxy-6-hydroxy-benzoyl)-3,5-dihydroxy-benzoic acid (1R,2R,4S)-2-(4-hydroxy-benzoylamino)-4-hydroxymethyl-cyclopentyl ester | CHEMBL75661 |
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| Type | Small organic molecule |
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| Emp. Form. | C28H25NO11 |
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| Mol. Mass. | 551.4982 |
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| SMILES | OC[C@H]1C[C@@H](NC(=O)c2ccc(O)cc2)[C@@H](C1)OC(=O)c1cc(O)c(C(=O)c2c(O)cccc2C(O)=O)c(O)c1 |
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| Structure | 
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