Search and Browse
Download
Enter Data
| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | cAMP-dependent protein kinase catalytic subunit alpha | ||
| Ligand | BDBM50055670 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_161873 (CHEMBL770106) | ||
| IC50 | 1700±n/a nM | ||
| Citation |  Lai, YS; Mendoza, JS; Jagdmann, GE; Menaldino, DS; Biggers, CK; Heerding, JM; Wilson, JW; Hall, SE; Jiang, JB; Janzen, WP; Ballas, LM Synthesis and protein kinase C inhibitory activities of balanol analogs with replacement of the perhydroazepine moiety. J Med Chem40:226-35 (1997) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| cAMP-dependent protein kinase catalytic subunit alpha | |||
| Name: | cAMP-dependent protein kinase catalytic subunit alpha | ||
| Synonyms: | KAPCA_HUMAN | PKA C-alpha | PKACA | PRKACA | cAMP-dependent protein kinase (PKA) | cAMP-dependent protein kinase catalytic (PKA) | cAMP-dependent protein kinase catalytic subunit alpha | cAMP-dependent protein kinase catalytic subunit alpha (PKA) | cAMP-dependent protein kinase catalytic subunit alpha (PKACA) | cAMP-dependent protein kinase catalytic subunit alpha (PKAc) | cAMP-dependent protein kinase catalytic subunit alpha isoform 1 | cAMP-dependent protein kinase, alpha-catalytic subunit | ||
| Type: | Enzyme Catalytic Subunit | ||
| Mol. Mass.: | 40598.73 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | n/a | ||
| Residue: | 351 | ||
| Sequence: |
| ||
| BDBM50055670 | |||
| n/a | |||
| Name | BDBM50055670 | ||
| Synonyms: | 4-(2-Carboxy-6-hydroxy-benzoyl)-3,5-dihydroxy-benzoic acid (3R,4R)-3-(4-hydroxy-benzoylamino)-1-aza-bicyclo[3.2.2]non-4-yl ester | CHEMBL78129 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C30H28N2O10 | ||
| Mol. Mass. | 576.5507 | ||
| SMILES | OC(=O)c1cccc(O)c1C(=O)c1c(O)cc(cc1O)C(=O)O[C@@H]1C2CCN(CC2)C[C@H]1NC(=O)c1ccc(O)cc1 |wU:23.24,wD:31.35,(5.05,-.22,;5.83,-1.57,;7.37,-1.57,;4.73,-2.67,;3.19,-2.67,;2.43,-4.01,;3.2,-5.33,;4.73,-5.33,;3.96,-6.66,;5.5,-4.01,;7.05,-4.01,;7.82,-2.67,;7.82,-5.34,;9.36,-5.33,;10.12,-3.98,;10.13,-6.66,;9.36,-8,;7.82,-8,;7.05,-6.67,;5.95,-7.76,;10.13,-9.34,;9.36,-10.69,;11.68,-9.34,;12.44,-10.37,;11.84,-11.54,;13.1,-11.2,;13.44,-12.46,;14.69,-12.12,;13.59,-13.01,;12.38,-12.68,;14.67,-10.97,;13.71,-10.12,;14.36,-8.72,;15.9,-8.71,;16.67,-10.04,;16.66,-7.37,;18.2,-7.37,;18.97,-6.04,;18.19,-4.7,;18.95,-3.35,;16.63,-4.71,;15.88,-6.06,)| | ||
| Structure | 
| ||