| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Thermolysin |
|---|
| Ligand | BDBM50056250 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_210396 (CHEMBL814126) |
|---|
| IC50 | 41000±n/a nM |
|---|
| Citation |  Ksander, GM; de Jesus, R; Yuan, A; Ghai, RD; Trapani, A; McMartin, C; Bohacek, R Ortho-substituted benzofused macrocyclic lactams as zinc metalloprotease inhibitors. J Med Chem40:495-505 (1997) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Thermolysin |
|---|
| Name: | Thermolysin |
|---|
| Synonyms: | THER_BACTH | npr |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 60097.54 |
|---|
| Organism: | Bacillus thermoproteolyticus |
|---|
| Description: | ChEMBL_1468794 |
|---|
| Residue: | 548 |
|---|
| Sequence: | MKMKMKLASFGLAAGLAAQVFLPYNALASTEHVTWNQQFQTPQFISGDLLKVNGTSPEEL
VYQYVEKNENKFKFHENAKDTLQLKEKKNDNLGFTFMRFQQTYKGIPVFGAVVTSHVKDG
TLTALSGTLIPNLDTKGSLKSGKKLSEKQARDIAEKDLVANVTKEVPEYEQGKDTEFVVY
VNGDEASLAYVVNLNFLTPEPGNWLYIIDAVDGKILNKFNQLDAAKPGDVKSITGTSTVG
VGRGVLGDQKNINTTYSTYYYLQDNTRGNGIFTYDAKYRTTLPGSLWADADNQFFASYDA
PAVDAHYYAGVTYDYYKNVHNRLSYDGNNAAIRSSVHYSQGYNNAFWNGSQMVYGDGDGQ
TFIPLSGGIDVVAHELTHAVTDYTAGLIYQNESGAINEAISDIFGTLVEFYANKNPDWEI
GEDVYTPGISGDSLRSMSDPAKYGDPDHYSKRYTGTQDNGGVHINSGIINKAAYLISQGG
THYGVSVVGIGRDKLGKIFYRALTQYLTPTSNFSQLRAAAVQSATDLYGSTSQEVASVKQ
AFDAVGVK
|
|
|
|---|
| BDBM50056250 |
|---|
| n/a |
|---|
| Name | BDBM50056250 |
|---|
| Synonyms: | (6S,9S)-6-Mercaptomethyl-7-oxo-6,7,8,9,10,11,12,13,14,15-decahydro-5H-8-aza-benzocyclotridecene-9-carboxylic acid | CHEMBL149841 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C18H25NO3S |
|---|
| Mol. Mass. | 335.461 |
|---|
| SMILES | OC(=O)[C@@H]1CCCCCCc2ccccc2C[C@H](CS)C(=O)N1 |
|---|
| Structure | 
|
|---|
Search and Browse
