| Reaction Details |
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 | Report a problem with these data |
| Target | Thermolysin |
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| Ligand | BDBM50056251 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_210396 (CHEMBL814126) |
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| IC50 | 4000±n/a nM |
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| Citation |  Ksander, GM; de Jesus, R; Yuan, A; Ghai, RD; Trapani, A; McMartin, C; Bohacek, R Ortho-substituted benzofused macrocyclic lactams as zinc metalloprotease inhibitors. J Med Chem40:495-505 (1997) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Thermolysin |
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| Name: | Thermolysin |
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| Synonyms: | THER_BACTH | npr |
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| Type: | PROTEIN |
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| Mol. Mass.: | 60097.54 |
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| Organism: | Bacillus thermoproteolyticus |
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| Description: | ChEMBL_1468794 |
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| Residue: | 548 |
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| Sequence: | MKMKMKLASFGLAAGLAAQVFLPYNALASTEHVTWNQQFQTPQFISGDLLKVNGTSPEEL
VYQYVEKNENKFKFHENAKDTLQLKEKKNDNLGFTFMRFQQTYKGIPVFGAVVTSHVKDG
TLTALSGTLIPNLDTKGSLKSGKKLSEKQARDIAEKDLVANVTKEVPEYEQGKDTEFVVY
VNGDEASLAYVVNLNFLTPEPGNWLYIIDAVDGKILNKFNQLDAAKPGDVKSITGTSTVG
VGRGVLGDQKNINTTYSTYYYLQDNTRGNGIFTYDAKYRTTLPGSLWADADNQFFASYDA
PAVDAHYYAGVTYDYYKNVHNRLSYDGNNAAIRSSVHYSQGYNNAFWNGSQMVYGDGDGQ
TFIPLSGGIDVVAHELTHAVTDYTAGLIYQNESGAINEAISDIFGTLVEFYANKNPDWEI
GEDVYTPGISGDSLRSMSDPAKYGDPDHYSKRYTGTQDNGGVHINSGIINKAAYLISQGG
THYGVSVVGIGRDKLGKIFYRALTQYLTPTSNFSQLRAAAVQSATDLYGSTSQEVASVKQ
AFDAVGVK
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| BDBM50056251 |
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| n/a |
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| Name | BDBM50056251 |
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| Synonyms: | (6R,9S)-6-Mercaptomethyl-7-oxo-5,6,7,8,9,10,11,12,13,14-decahydro-8-aza-benzocyclododecene-9-carboxylic acid | CHEMBL357311 |
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| Type | Small organic molecule |
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| Emp. Form. | C17H23NO3S |
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| Mol. Mass. | 321.434 |
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| SMILES | OC(=O)[C@@H]1CCCCCc2ccccc2C[C@@H](CS)C(=O)N1 |
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| Structure | 
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