Reaction Details |
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Target | Neprilysin |
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Ligand | BDBM50056257 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_144636 (CHEMBL752994) |
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IC50 | 900±n/a nM |
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Citation | Ksander, GM; de Jesus, R; Yuan, A; Ghai, RD; McMartin, C; Bohacek, R Meta-substituted benzofused macrocyclic lactams as zinc metalloprotease inhibitors. J Med Chem40:506-14 (1997) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Neprilysin |
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Name: | Neprilysin |
Synonyms: | Atriopeptidase | CALLA | CD_antigen=CD10 | Common acute lymphocytic leukemia antigen | EPN | Enkephalinase | MME | NEP | NEP_HUMAN | Neutral Endopeptidase (NEP) | Neutral endopeptidase | Neutral endopeptidase 24.11 |
Type: | Enzyme |
Mol. Mass.: | 85505.38 |
Organism: | Homo sapiens (Human) |
Description: | P08473 |
Residue: | 750 |
Sequence: | MGKSESQMDITDINTPKPKKKQRWTPLEISLSVLVLLLTIIAVTMIALYATYDDGICKSS
DCIKSAARLIQNMDATTEPCTDFFKYACGGWLKRNVIPETSSRYGNFDILRDELEVVLKD
VLQEPKTEDIVAVQKAKALYRSCINESAIDSRGGEPLLKLLPDIYGWPVATENWEQKYGA
SWTAEKAIAQLNSKYGKKVLINLFVGTDDKNSVNHVIHIDQPRLGLPSRDYYECTGIYKE
ACTAYVDFMISVARLIRQEERLPIDENQLALEMNKVMELEKEIANATAKPEDRNDPMLLY
NKMTLAQIQNNFSLEINGKPFSWLNFTNEIMSTVNISITNEEDVVVYAPEYLTKLKPILT
KYSARDLQNLMSWRFIMDLVSSLSRTYKESRNAFRKALYGTTSETATWRRCANYVNGNME
NAVGRLYVEAAFAGESKHVVEDLIAQIREVFIQTLDDLTWMDAETKKRAEEKALAIKERI
GYPDDIVSNDNKLNNEYLELNYKEDEYFENIIQNLKFSQSKQLKKLREKVDKDEWISGAA
VVNAFYSSGRNQIVFPAGILQPPFFSAQQSNSLNYGGIGMVIGHEITHGFDDNGRNFNKD
GDLVDWWTQQSASNFKEQSQCMVYQYGNFSWDLAGGQHLNGINTLGENIADNGGLGQAYR
AYQNYIKKNGEEKLLPGLDLNHKQLFFLNFAQVWCGTYRPEYAVNSIKTDVHSPGNFRII
GTLQNSAEFSEAFHCRKNSYMNPEKKCRVW
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BDBM50056257 |
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n/a |
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Name | BDBM50056257 |
Synonyms: | (6S,9S)-9-Mercaptomethyl-8-oxo-5,6,7,8,9,10,11,12,13,14,15,16-dodecahydro-7-aza-benzocyclotetradecene-6-carboxylic acid | CHEMBL433702 |
Type | Small organic molecule |
Emp. Form. | C19H27NO3S |
Mol. Mass. | 349.488 |
SMILES | OC(=O)[C@@H]1Cc2ccccc2CCCCCCC[C@H](CS)C(=O)N1 |
Structure |
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