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Target72 kDa type IV collagenase
LigandBDBM50057044
Substrate/Competitorn/a
Meas. Tech.ChEMBL_104543 (CHEMBL718930)
Ki 34±n/a nM
Citation Esser, CKBugianesi, RLCaldwell, CGChapman, KTDurette, PLGirotra, NNKopka, IELanza, TJLevorse, DAMacCoss, MOwens, KAPonpipom, MMSimeone, JPHarrison, RKNiedzwiecki, LBecker, JWMarcy, AIAxel, MGChristen, AJMcDonnell, JMoore, VLOlszewski, JMSaphos, CVisco, DMHagmann, WK Inhibition of stromelysin-1 (MMP-3) by P1'-biphenylylethyl carboxyalkyl dipeptides. J Med Chem40:1026-40 (1997) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
72 kDa type IV collagenase
Name:72 kDa type IV collagenase
Synonyms:72 kDa gelatinase | 72 kDa type IV collagenase precursor | CLG4A | Gelatinase A | Gelatinase A (MMP-2) | MMP2 | MMP2_HUMAN | Matrix metalloproteinase-2 | Matrix metalloproteinase-2 (MMP 2) | Matrix metalloproteinase-2 (MMP2) | Matrix metalloproteinases 2 (MMP-2) | TBE-1
Type:Enzyme
Mol. Mass.:73870.36
Organism:Homo sapiens (Human)
Description: P08253
Residue:660
Sequence:
MEALMARGALTGPLRALCLLGCLLSHAAAAPSPIIKFPGDVAPKTDKELAVQYLNTFYGC
PKESCNLFVLKDTLKKMQKFFGLPQTGDLDQNTIETMRKPRCGNPDVANYNFFPRKPKWD
KNQITYRIIGYTPDLDPETVDDAFARAFQVWSDVTPLRFSRIHDGEADIMINFGRWEHGD
GYPFDGKDGLLAHAFAPGTGVGGDSHFDDDELWTLGEGQVVRVKYGNADGEYCKFPFLFN
GKEYNSCTDTGRSDGFLWCSTTYNFEKDGKYGFCPHEALFTMGGNAEGQPCKFPFRFQGT
SYDSCTTEGRTDGYRWCGTTEDYDRDKKYGFCPETAMSTVGGNSEGAPCVFPFTFLGNKY
ESCTSAGRSDGKMWCATTANYDDDRKWGFCPDQGYSLFLVAAHEFGHAMGLEHSQDPGAL
MAPIYTYTKNFRLSQDDIKGIQELYGASPDIDLGTGPTPTLGPVTPEICKQDIVFDGIAQ
IRGEIFFFKDRFIWRTVTPRDKPMGPLLVATFWPELPEKIDAVYEAPQEEKAVFFAGNEY
WIYSASTLERGYPKPLTSLGLPPDVQRVDAAFNWSKNKKTYIFAGDKFWRYNEVKKKMDP
GFPKLIADAWNAIPDNLDAVVDLQGGGHSYFFKGAYYLKLENQSLKSVKFGSIKSDWLGC
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50057044
n/a
NameBDBM50057044
Synonyms:(2S,4R)-2-Butyl-4-((S)-2,2-dimethyl-1-methylcarbamoyl-propylcarbamoyl)-6-(4'-methylcarbamoyl-biphenyl-4-yl)-hexanoic acid | CHEMBL8930
TypeSmall organic molecule
Emp. Form.C32H45N3O5
Mol. Mass.551.7168
SMILESCCCC[C@@H](C[C@@H](CCc1ccc(cc1)-c1ccc(cc1)C(=O)NC)C(=O)N[C@H](C(=O)NC)C(C)(C)C)C(O)=O
Structure
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