| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Stromelysin-1 |
|---|
| Ligand | BDBM50057073 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_104738 (CHEMBL710738) |
|---|
| Ki | 2±n/a nM |
|---|
| Citation |  Esser, CK; Bugianesi, RL; Caldwell, CG; Chapman, KT; Durette, PL; Girotra, NN; Kopka, IE; Lanza, TJ; Levorse, DA; MacCoss, M; Owens, KA; Ponpipom, MM; Simeone, JP; Harrison, RK; Niedzwiecki, L; Becker, JW; Marcy, AI; Axel, MG; Christen, AJ; McDonnell, J; Moore, VL; Olszewski, JM; Saphos, C; Visco, DM; Hagmann, WK Inhibition of stromelysin-1 (MMP-3) by P1'-biphenylylethyl carboxyalkyl dipeptides. J Med Chem40:1026-40 (1997) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Stromelysin-1 |
|---|
| Name: | Stromelysin-1 |
|---|
| Synonyms: | MMP-3 | MMP3 | MMP3_HUMAN | Matrix metalloproteinase (2 and 3) | Matrix metalloproteinase 3 | Matrix metalloproteinase-3 | Matrix metalloproteinase-3 (MMP-3) | Matrix metalloproteinase-3 (MMP3) | SL-1 | STMY1 | Stromelysin 1 | Transin-1 |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 53973.13 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P08254 |
|---|
| Residue: | 477 |
|---|
| Sequence: | MKSLPILLLLCVAVCSAYPLDGAARGEDTSMNLVQKYLENYYDLKKDVKQFVRRKDSGPV
VKKIREMQKFLGLEVTGKLDSDTLEVMRKPRCGVPDVGHFRTFPGIPKWRKTHLTYRIVN
YTPDLPKDAVDSAVEKALKVWEEVTPLTFSRLYEGEADIMISFAVREHGDFYPFDGPGNV
LAHAYAPGPGINGDAHFDDDEQWTKDTTGTNLFLVAAHEIGHSLGLFHSANTEALMYPLY
HSLTDLTRFRLSQDDINGIQSLYGPPPDSPETPLVPTEPVPPEPGTPANCDPALSFDAVS
TLRGEILIFKDRHFWRKSLRKLEPELHLISSFWPSLPSGVDAAYEVTSKDLVFIFKGNQF
WAIRGNEVRAGYPRGIHTLGFPPTVRKIDAAISDKEKNKTYFFVEDKYWRFDEKRNSMEP
GFPKQIAEDFPGIDSKIDAVFEEFGFFYFFTGSSQLEFDPNAKKVTHTLKSNSWLNC
|
|
|
|---|
| BDBM50057073 |
|---|
| n/a |
|---|
| Name | BDBM50057073 |
|---|
| Synonyms: | (2S,4R)-6-(4'-Fluoro-biphenyl-4-yl)-4-((S)-3-methyl-1-phenylcarbamoyl-butylcarbamoyl)-2-[4-(1-oxo-1,3-dihydro-isoindol-2-yl)-butyl]-hexanoic acid | 6-(4'-FLUORO-BIPHENYL-4-YL)-4-(3-METHYL-1-PHENYLCARBAMOYL-BUTYLCARBAMOYL)-2-[4-(1-OXO-1,3-DIHYDRO-ISOINDOL-2-YL)-BUTYL]-HEXANOIC ACID | CHEMBL8933 | L-764004 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C43H48FN3O5 |
|---|
| Mol. Mass. | 705.8567 |
|---|
| SMILES | CC(C)C[C@H](NC(=O)[C@H](CCc1ccc(cc1)-c1ccc(F)cc1)C[C@H](CCCCN1Cc2ccccc2C1=O)C(O)=O)C(=O)Nc1ccccc1 |
|---|
| Structure | 
|
|---|
Search and Browse
