Reaction Details |
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Target | Endothelin-1 receptor |
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Ligand | BDBM50057194 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_65465 (CHEMBL682105) |
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IC50 | 2.1±n/a nM |
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Citation | Patt, WC; Edmunds, JJ; Repine, JT; Berryman, KA; Reisdorph, BR; Lee, C; Plummer, MS; Shahripour, A; Haleen, SJ; Keiser, JA; Flynn, MA; Welch, KM; Reynolds, EE; Rubin, R; Tobias, B; Hallak, H; Doherty, AM Structure-activity relationships in a series of orally active gamma-hydroxy butenolide endothelin antagonists. J Med Chem40:1063-74 (1997) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Endothelin-1 receptor |
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Name: | Endothelin-1 receptor |
Synonyms: | EDNRA | EDNRA_HUMAN | ET-A | ETA | ETA-R | ETRA | Endothelin receptor type A | Endothelin receptor, ET-A/ET-B | hET-AR |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 48736.88 |
Organism: | Homo sapiens (Human) |
Description: | P25101 |
Residue: | 427 |
Sequence: | METLCLRASFWLALVGCVISDNPERYSTNLSNHVDDFTTFRGTELSFLVTTHQPTNLVLP
SNGSMHNYCPQQTKITSAFKYINTVISCTIFIVGMVGNATLLRIIYQNKCMRNGPNALIA
SLALGDLIYVVIDLPINVFKLLAGRWPFDHNDFGVFLCKLFPFLQKSSVGITVLNLCALS
VDRYRAVASWSRVQGIGIPLVTAIEIVSIWILSFILAIPEAIGFVMVPFEYRGEQHKTCM
LNATSKFMEFYQDVKDWWLFGFYFCMPLVCTAIFYTLMTCEMLNRRNGSLRIALSEHLKQ
RREVAKTVFCLVVIFALCWFPLHLSRILKKTVYNEMDKNRCELLSFLLLMDYIGINLATM
NSCINPIALYFVSKKFKNCFQSCLCCCCYQSKSLMTSVPMNGTSIQWKNHDQNNHNTDRS
SHKDSMN
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BDBM50057194 |
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n/a |
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Name | BDBM50057194 |
Synonyms: | 3-Benzo[1,3]dioxol-5-yl-4-(2,5-dimethoxy-benzyl)-5-hydroxy-5-(4-methoxy-phenyl)-5H-furan-2-one | CHEMBL273723 |
Type | Small organic molecule |
Emp. Form. | C27H24O8 |
Mol. Mass. | 476.4747 |
SMILES | COc1ccc(cc1)C1(O)OC(=O)C(=C1Cc1cc(OC)ccc1OC)c1ccc2OCOc2c1 |c:14| |
Structure |
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